Radionuclide imaging for the assessment of esophageal motility disorders in mixed connective tissue disease patients: relation to pulmonary impairment

Esophageal functional abnormalities may lead to regurgitation, chronic esophagitis and life‐threatening conditions such as aspiration pneumonia. In mixed connective tissue disease patients, previous reports showed that esophageal dysfunction varies according to the method employed for investigation....

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Bibliographic Details
Published in:Diseases of the esophagus 2006-10, Vol.19 (5), p.394-400
Main Authors: Caleiro, M. T. C., Lage, L. V., Navarro-Rodriguez, T., Bresser, A., Da Costa, P. A., Yoshinari, N. H.
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Deglutition Disorders - etiology
Endoscopy, Digestive System
esophageal motility disorders
Esophageal Motility Disorders - complications
Esophageal Motility Disorders - diagnostic imaging
Esophagitis - diagnostic imaging
Female
Gastritis - complications
gastroesophageal reflux
Heartburn - etiology
Hernia, Hiatal - complications
Humans
interstitial lung disease
Lung Diseases - complications
Male
Middle Aged
mixed connective tissue disease
Mixed Connective Tissue Disease - complications
Mucociliary Clearance
Radionuclide Imaging
Respiratory Function Tests
Surveys and Questionnaires
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Summary:Esophageal functional abnormalities may lead to regurgitation, chronic esophagitis and life‐threatening conditions such as aspiration pneumonia. In mixed connective tissue disease patients, previous reports showed that esophageal dysfunction varies according to the method employed for investigation. Our study was conceived to: (i) assess esophageal motility and mucosal aspects in patients with mixed connective tissue disease by endoscopy, cine‐esophogram and scintigraphy focusing on the prevalence of each exam; and (ii) verify the association between pulmonary and esophageal dysfunctions. Twenty‐four mixed connective tissue disease patients were enrolled for this study. Cine‐esophogram and upper digestive endoscopy with mucosal biopsy were performed according to previous standardization. Radionuclide esophageal scintigraphy was performed with a semisolid meal with 99mTc. Eleven healthy individuals voluntarily submitted to scintigraphy as controls. Cine‐esophogram showed esophageal delayed emptying in 90% of patients. At scintigraphy there was a significant delay in total esophageal transit time in the group of patients when compared to healthy controls (35.3 ± 8.2 s. vs. 13.6 ± 9.5 s.; P 
ISSN:1120-8694
1442-2050
DOI:10.1111/j.1442-2050.2006.00598.x