Acute hemolytic transfusion reaction in a pediatric patient following transfusion of apheresis platelets

The practice of transfusing ABO‐incompatible platelets, driven primarily by concerns about inventory management, has been considered generally safe because the accompanying plasma is usually diluted in the recipient's total blood volume. However, if the platelet product contains a large volume...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical apheresis 2005-12, Vol.20 (4), p.225-229
Main Authors: Sapatnekar, Suneeti, Sharma, Girish, Downes, Katharine A., Wiersma, Susan, McGrath, Claire, Yomtovían, Roslyn
Format: Article
Language:English
Subjects:
ABO blood groups
ABO Blood-Group System
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Volume
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Brain Stem Neoplasms - blood
Brain Stem Neoplasms - complications
Brain Stem Neoplasms - therapy
Child, Preschool
Drug toxicity and drugs side effects treatment
Emergency and intensive care: renal failure. Dialysis management
Female
Hemagglutinins - blood
Hemolysis
Humans
Intensive care medicine
Medical sciences
Pharmacology. Drug treatments
platelet transfusion
Platelet Transfusion - adverse effects
Toxicity: urogenital system
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The practice of transfusing ABO‐incompatible platelets, driven primarily by concerns about inventory management, has been considered generally safe because the accompanying plasma is usually diluted in the recipient's total blood volume. However, if the platelet product contains a large volume of plasma or a high concentration of incompatible isoagglutinin, there may be hemolysis of the recipient's red cells. Patients with a small blood volume, such as babies and children, are considered to be at particular risk for such a complication. We describe the case of a baby who suffered massive hemolysis of her group A red cells after transfusion of group O Apheresis Platelets containing a high‐titered anti‐A isoagglutinin. We also offer a review of the literature on this subject and recommendations to avoid acute hemolytic reactions as a result of platelet transfusion. J. Clin. Apheresis 2005. © 2005 Wiley‐Liss, Inc.
ISSN:0733-2459
1098-1101
DOI:10.1002/jca.20072