Cellular aspects of liver regeneration

This paper has the objective to analyze the cellular aspects of liver regeneration (LR). Upon damage in this organ, the regenerative capacity of hepatocyte is sufficiently able to reestablish the parenchyma as a whole. Taking into account the regenerative capacity of hepatocyte, the need of a progen...

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Bibliographic Details
Published in:Acta cirúrgica brasileira 2006, Vol.21 Suppl 1 (suppl 1), p.63-66
Main Authors: Tarlá, Marissa Rabelo, Ramalho, Fernando, Ramalho, Leandra Naira Zambelli, Silva, Tiago de Castro e, Brandão, Daniel Ferracioli, Ferreira, Juliana, Silva, Orlando de Castro e, Zucoloto, Sérgio
Format: Article
Language:English
Subjects:
Animals
Antigens, Surface - metabolism
Bile Ducts - cytology
Biomarkers - metabolism
Cell Differentiation - physiology
Cell Proliferation
Hematopoietic Stem Cells - cytology
Hepatocytes - cytology
Humans
Liver Regeneration - physiology
Rats
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Summary:This paper has the objective to analyze the cellular aspects of liver regeneration (LR). Upon damage in this organ, the regenerative capacity of hepatocyte is sufficiently able to reestablish the parenchyma as a whole. Taking into account the regenerative capacity of hepatocyte, the need of a progenitor or a liver trunk cell was not obvious. Nowadays it is well-established that precursor cells take part in the liver regenerative process. The liver trunk cell, oval cell, acts as a by-potential precursor, contributing for the liver restoration, mainly when the hepatocytes are unable to proliferate. Another precursor, trunk cell of hematopoetic origin (HSC), takes part in the regenerative process, originating cells of the hepatocytic lineage and colangiocytes, as well as the oval cell. The way the trans-differentiation takes place is not established yet. A number of studies must be undertaken in order to clarify questions, such as the possible occurrence of cellular fusion process between the HSC and the hepatic cells and the possibility of application as a new therapeutic procedure in the treatment of diseases associated with insufficiency of this noble organ.
ISSN:0102-8650
0102-8650
DOI:10.1590/s0102-86502006000700015