Asymmetrical dimethylarginine is related to renal function, chronic inflammation and macroangiopathy in patients with Type 2 diabetes and albuminuria

Aims  Patients with Type 2 diabetes mellitus (T2DM) and micro‐ and macroalbuminuria are at increased cardiovascular risk. The endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) is increased in renal failure and could promote atherosclerosis. To determine the relationship...

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Bibliographic Details
Published in:Diabetic medicine 2007-01, Vol.24 (1), p.81-86
Main Authors: Krzyzanowska, K., Mittermayer, F., Shnawa, N., Hofer, M., Schnabler, J., Etmüller, Y., Kapiotis, S., Wolzt, M., Schernthaner, G.
Format: Article
Language:English
Subjects:
Aged
albuminuria
Albuminuria - etiology
Arginine - analogs & derivatives
Arginine - urine
asymmetrical dimethylarginine
Atherosclerosis - etiology
Biological and medical sciences
Diabetes Mellitus, Type 2 - urine
Diabetes. Impaired glucose tolerance
Diabetic Angiopathies - urine
Diabetic Nephropathies - urine
diabetic nephropathy
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Humans
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - urine
macrovascular disease
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Type 2 diabetes mellitus
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
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Summary:Aims  Patients with Type 2 diabetes mellitus (T2DM) and micro‐ and macroalbuminuria are at increased cardiovascular risk. The endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) is increased in renal failure and could promote atherosclerosis. To determine the relationship between ADMA, renal albumin excretion rate (AER) and cardiovascular risk, we studied 103 T2DM patients. Methods  ADMA, symmetrical dimethylarginine (SDMA) and L‐arginine were determined by high‐performance liquid chromatography in plasma from 36 normo‐, 40 micro‐ and 27 macroalbuminuric patients with T2DM (age 64 ± 11 years; 38 women) who had comparable age, sex and metabolic parameters. Forty‐six patients had macrovascular disease (MVD). Results  ADMA was significantly increased in patients with micro‐ and macroalbuminuria [median 0.61 (interquartile range 0.55–0.70) µmol/l and 0.62 (0.50–0.79) µmol/l, respectively] compared with those with normoalbuminuria [0.55 (0.48–0.63) µmol/l; both P 
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2007.02018.x