Prevention of catheter-related bacteremia in pediatric intestinal transplantation/short gut syndrome children with long-term central venous catheters

:  Catheter‐related bacteremia (CRB), along with liver failure is the leading cause of mortality and morbidity in parenteral nutrition dependent children. Immunosuppressant therapy following transplantation increases the risk of CRB. Previous reports in pediatric cancer patients have described the u...

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Published in:Pediatric transplantation 2007-02, Vol.11 (1), p.87-93
Main Authors: Onder, Ali Mirza, Kato, Tomoaki, Simon, Nancy, Rivera-Hernandez, Maria, Chandar, Jayanthi, Montane, Brenda, Francoeur, Denise, Salvaggi, Genaro, Tzakis, Andreas G., Zilleruelo, Gaston
Format: Article
Language:English
Subjects:
antibiotic-lock solutions
Bacteremia - prevention & control
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
catheter survival
catheter-related bacteremia
Catheterization, Central Venous - adverse effects
Child
Child, Preschool
Female
Follow-Up Studies
Human bacterial diseases
Humans
Infant
Infectious diseases
Intestines - transplantation
Kidney Transplantation
Liver Transplantation
Male
Medical sciences
parenteral nutrition
Prevention and actions
prophylaxis
Public health. Hygiene
Public health. Hygiene-occupational medicine
Retrospective Studies
Short Bowel Syndrome - surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Summary::  Catheter‐related bacteremia (CRB), along with liver failure is the leading cause of mortality and morbidity in parenteral nutrition dependent children. Immunosuppressant therapy following transplantation increases the risk of CRB. Previous reports in pediatric cancer patients have described the use of antibiotic lock solutions (ABL) for prophylaxis of CRB. In our institution, we evaluated five children (ages between one and four yr old), three with intestinal transplantation and two with short gut syndrome, who were high risk for recurrent CRB defined by their incidence of bacteremias in the observation period (>2 CRB/six months or life‐threatening CRB). These children received the prophylactic ABL protocol with tobramycin‐tissue plasminogen activator, four h per day, on alternating ports for six to eight months. Each patient was his/her own historical control. We observed decreased incidence of CRB's (p 
ISSN:1397-3142
1399-3046
DOI:10.1111/j.1399-3046.2006.00634.x