Polymer-Based Paclitaxel-Eluting Stents Are Superior to Nonpolymer-Based Paclitaxel-Eluting Stents in the Treatment of De Novo Coronary Lesions

Although polymer coating of coronary stents enables sufficient loading and release of incorporated drugs, it has also been associated with potentially negative effects. This study compared the clinical, angiographic, and intravascular ultrasound (IVUS) outcomes of patients treated with polymer- vers...

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Bibliographic Details
Published in:The American journal of cardiology 2006-10, Vol.98 (8), p.1022-1027
Main Authors: Iofina, Ekaterina, Langenberg, Roswitha, Blindt, Rüdiger, Kühl, Harald, Kelm, Malte, Hoffmann, Rainer
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Clinical outcomes
Comparative studies
Coronary Angiography
Coronary heart disease
Coronary Stenosis - mortality
Coronary Stenosis - therapy
Female
Follow-Up Studies
Heart
Humans
Male
Medical sciences
Middle Aged
Paclitaxel - administration & dosage
Polymers
Recurrence
Stents
Survival Rate
Treatment Outcome
Tubulin Modulators - administration & dosage
Ultrasonography, Interventional
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Summary:Although polymer coating of coronary stents enables sufficient loading and release of incorporated drugs, it has also been associated with potentially negative effects. This study compared the clinical, angiographic, and intravascular ultrasound (IVUS) outcomes of patients treated with polymer- versus nonpolymer-based paclitaxel-eluting stents (PESs). Sixty-five consecutive patients (70 de novo lesions) treated with polymer-based PESs (TAXUS, 1 μg/mm 2 of paclitaxel; Boston Scientific Corp.) and 65 consecutive patients (65 de novo lesions) treated with nonpolymer-based PESs (V-Flex Plus, 2.7 μg/mm 2 of paclitaxel; Cook, Inc.) were enrolled in the study. Six-month angiographic follow-up was performed on 54 lesions of the polymer-based PES group and 51 lesions of the nonpolymer-based PES group. IVUS at angiographic follow-up was performed in 61 of the first 70 included lesions. At 6-month IVUS follow-up, mean intimal hyperplasia cross-sectional area was 2.36 ± 1.60 mm 2 in the nonpolymer-based PES group versus 0.62 ± 0.41 mm 2 in the polymer-based PES group (p = 0.003). Implantation of polymer-based PESs resulted in significantly lower in-stent late lumen loss (0.22 ± 0.27 vs 0.74 ± 0.61 mm, respectively, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2006.05.019