Acute fright induces onset of symptoms in vanishing white matter disease—Case report

Vanishing white matter disease is a newly recognised leukoencephalopathy of identified genetic background, characterised by cystic degeneration and progressive vanishing of white matter. The characteristic clinical symptoms are spasticity and ataxia with relatively preserved cognitive functions. A c...

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Bibliographic Details
Published in:European journal of paediatric neurology 2006-07, Vol.10 (4), p.192-193
Main Authors: Kaczorowska, M., Kuczynski, D., Jurkiewicz, E., Scheper, G.C., van der Knaap, M.S., Jozwiak, S.
Format: Article
Language:English
Subjects:
Brain Diseases - complications
Brain Diseases - genetics
Brain Diseases - pathology
Child
DNA - genetics
Fear - physiology
Female
Gait Disorders, Neurologic - etiology
Gait Disorders, Neurologic - pathology
Humans
Leukoencephalopathy
Muscle Spasticity - etiology
Muscle Spasticity - pathology
Mutation - genetics
Stress
Vanishing white matter
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Summary:Vanishing white matter disease is a newly recognised leukoencephalopathy of identified genetic background, characterised by cystic degeneration and progressive vanishing of white matter. The characteristic clinical symptoms are spasticity and ataxia with relatively preserved cognitive functions. A characteristic feature of the disease is the occurrence of the symptoms after a physical stress situation such as mild head trauma or febrile infection. We would like to present a case of a 6-year-old girl whose first symptoms of the disease occurred after being frightened by a horse.
ISSN:1090-3798
1532-2130
DOI:10.1016/j.ejpn.2006.05.008