A General and Efficient FeCl3-Catalyzed Nucleophilic Substitution of Propargylic Alcohols

A general and efficient FeCl3-catalyzed substitution reaction of propargylic alcohols with carbon- and heteroatom-centered nucleophiles such as allyl trimethylsilane, alcohols, aromatic compounds, thiols, and amides, leading to the construction of C−C, C−O, C−S and C−N bonds, has been developed....

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Bibliographic Details
Published in:Journal of organic chemistry 2006-10, Vol.71 (21), p.8298-8301
Main Authors: Zhan, Zhuang-ping, Yu, Jing-liang, Liu, Hui-juan, Cui, Yuan-yuan, Yang, Rui-feng, Yang, Wen-zhen, Li, Jun-ping
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Catalysis
Chemistry
Chlorides
Exact sciences and technology
Ferric Compounds - chemistry
Organic chemistry
Propanols - chemistry
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Summary:A general and efficient FeCl3-catalyzed substitution reaction of propargylic alcohols with carbon- and heteroatom-centered nucleophiles such as allyl trimethylsilane, alcohols, aromatic compounds, thiols, and amides, leading to the construction of C−C, C−O, C−S and C−N bonds, has been developed.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo061234p