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Identification and genetic diversity of two human parvovirus B19 genotype 3 subtypes

1 Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK 2 Department of Genetics, University of Cambridge, Cambridge, UK 3 National Blood Service, Cambridge Blood Centre, Cambridge, UK Correspondence Daniel Candotti dc241{at}cam.ac.uk Three genotypes (1–...

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Published in:Journal of general virology 2007-02, Vol.88 (2), p.428-431
Main Authors: Parsyan, Armen, Szmaragd, Camille, Allain, Jean-Pierre, Candotti, Daniel
Format: Article
Language:English
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Summary:1 Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK 2 Department of Genetics, University of Cambridge, Cambridge, UK 3 National Blood Service, Cambridge Blood Centre, Cambridge, UK Correspondence Daniel Candotti dc241{at}cam.ac.uk Three genotypes (1–3) of human parvovirus B19 have been identified. Analysis of 13 nearly full-length genotype 3 sequences from Ghana, Europe and Brazil identified two genetically distinct clusters. The classification of genotype 3 strains into two subtypes (B19/3a and B19/3b) is proposed. The rate of evolutionary change of B19 genotype 3 strains (2 x 10 –4  nucleotide substitutions per site per year) was similar to those of B19 genotype 1 and carnivore parvoviruses, supporting the hypothesis that high mutation rates are characteristic of members of the family Parvoviridae . The estimated divergence time between B19/3a and B19/3b is 525 years. In Ghana, subtype B19/3a is predominant. The GenBank/EMBL/DDBJ accession numbers for the Ghanaian B19 sequences obtained in this study are AY582124, AY582125, DQ234769, DQ234771, DQ234775, DQ234778 and DQ234779.
ISSN:0022-1317
1465-2099
DOI:10.1099/vir.0.82496-0