Adiponectin, insulin resistance and clinical expression of the metabolic syndrome in patients with Type 2 diabetes

Background: Obesity and the metabolic syndrome have emerged as clinical and public health crises in many populations, but not all obese patients have the syndrome. As adipocytes produce several adipokines that modulate insulin action as well as glucose and lipid metabolism, we postulate that estimat...

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Bibliographic Details
Published in:International Journal of Obesity 2007-02, Vol.31 (2), p.213-220
Main Authors: Mojiminiyi, O.A, Abdella, N.A, Al Arouj, M, Ben Nakhi, A
Format: Article
Language:English
Subjects:
adipocytes
adipokinetic hormone
Adiponectin - blood
Adult
adults
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers - blood
Blood
blood chemistry
blood glucose
blood lipids
body fat
C-reactive protein
carbohydrate metabolism
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - etiology
Diabetes. Impaired glucose tolerance
diagnostic techniques
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Epidemiology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
glucose
Health Promotion and Disease Prevention
hemoglobin
hormones
Humans
insulin
Insulin Resistance
Internal Medicine
Leptin - blood
lipid metabolism
Lipids - blood
Male
Medical sciences
Medicine
Medicine & Public Health
men
Metabolic Diseases
Metabolic disorders
metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - diagnosis
Metabolic Syndrome - etiology
Middle Aged
Miscellaneous
noninsulin-dependent diabetes mellitus
Obesity
Obesity - blood
Obesity - complications
original-article
Other metabolic disorders
patients
Public Health
Sensitivity and Specificity
Vertebrates: anatomy and physiology, studies on body, several organs or systems
women
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Summary:Background: Obesity and the metabolic syndrome have emerged as clinical and public health crises in many populations, but not all obese patients have the syndrome. As adipocytes produce several adipokines that modulate insulin action as well as glucose and lipid metabolism, we postulate that estimation of adipokines may be useful addition to the criteria used to identify obese individuals with the metabolic syndrome. Objective: To evaluate the determinants and associations of plasma adiponectin in relation to the metabolic syndrome in patients with Type 2 diabetes. Design: Cross-sectional study. Setting: General Teaching Hospital. Patients: One hundred and thirty five (57 M, 78 F) patients with Type 2 diabetes mellitus. Measurements: Adiponectin, leptin, high-sensitivity C-reactive protein (hs-CRP), fasting plasma insulin, glucose, glycated hemoglobin and full lipid profile. Patients were classified on the basis of the degree of adiposity, insulin resistance (IR) (homeostasis model assessment of insulin resistance (HOMA-IR)) and the number of the American Heart Association and the National Heart, Lung and Blood Institute criteria of the metabolic syndrome. Results: Adiponectin levels were inversely correlated with age, indices of obesity, IR and hs-CRP. Overweight/obese and non-obese insulin-sensitive patients had significantly higher (P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0803355