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Human papillomavirus-16 in oral squamous cell carcinoma: Clinical correlates and 5-year survival
Abstract We examined 66 oral squamous cell carcinomas (OSCCs) for human papillomavirus-16 (HPV-16) infection to evaluate its prognostic significance. Cox regression analysis of 5-year survival demonstrated that patients without nodal metastasis or with intratumoural HPV-16 showed better prognoses co...
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| Published in: | British journal of oral & maxillofacial surgery 2007-03, Vol.45 (2), p.116-122 |
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| container_end_page | 122 |
| container_issue | 2 |
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| container_title | British journal of oral & maxillofacial surgery |
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| creator | Sugiyama, Masaru Bhawal, Ujjal Kumar Kawamura, Makoto Ishioka, Yasuki Shigeishi, Hideo Higashikawa, Koichiro Kamata, Nobuyuki |
| description | Abstract We examined 66 oral squamous cell carcinomas (OSCCs) for human papillomavirus-16 (HPV-16) infection to evaluate its prognostic significance. Cox regression analysis of 5-year survival demonstrated that patients without nodal metastasis or with intratumoural HPV-16 showed better prognoses compared with each counterpart. In Kaplan-Meier survival analysis, nodal status but not HPV-16 status was statistically significant. The 5-year survival rate of HPV-16 positive patients without nodal metastasis (94%) was extremely high, compared with that of HPV-16 negative patients with nodal metastasis (25%). These results suggest that HPV-16 status as well as nodal status may provide prognostic significance in patients with OSCC. |
| doi_str_mv | 10.1016/j.bjoms.2006.04.012 |
| format | article |
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Cox regression analysis of 5-year survival demonstrated that patients without nodal metastasis or with intratumoural HPV-16 showed better prognoses compared with each counterpart. In Kaplan-Meier survival analysis, nodal status but not HPV-16 status was statistically significant. The 5-year survival rate of HPV-16 positive patients without nodal metastasis (94%) was extremely high, compared with that of HPV-16 negative patients with nodal metastasis (25%). These results suggest that HPV-16 status as well as nodal status may provide prognostic significance in patients with OSCC.</description><identifier>ISSN: 0266-4356</identifier><identifier>EISSN: 1532-1940</identifier><identifier>DOI: 10.1016/j.bjoms.2006.04.012</identifier><identifier>PMID: 16781026</identifier><identifier>CODEN: BJOSEY</identifier><language>eng</language><publisher>Londonc: Elsevier Ltd</publisher><subject>5-year survival ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - virology ; Clinical correlates ; Dentistry ; Disease-Free Survival ; DNA, Viral - analysis ; Female ; Human papillomavirus 16 - isolation & purification ; Human papillomavirus-16 ; Humans ; Kaplan-Meier Estimate ; Logistic Models ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Mouth Neoplasms - mortality ; Mouth Neoplasms - virology ; Multivariate analysis ; Oral squamous cell carcinoma ; Otorhinolaryngology. Stomatology ; Papillomavirus Infections - mortality ; Proportional Hazards Models ; Surgery ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>British journal of oral & maxillofacial surgery, 2007-03, Vol.45 (2), p.116-122</ispartof><rights>The British Association of Oral and Maxillofacial Surgeons</rights><rights>2006 The British Association of Oral and Maxillofacial Surgeons</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-9ce9e79dcaa19f6269d32dc3b951293c617c63063812efa96980ea3f4f25c2873</citedby><cites>FETCH-LOGICAL-c442t-9ce9e79dcaa19f6269d32dc3b951293c617c63063812efa96980ea3f4f25c2873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18502626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16781026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugiyama, Masaru</creatorcontrib><creatorcontrib>Bhawal, Ujjal Kumar</creatorcontrib><creatorcontrib>Kawamura, Makoto</creatorcontrib><creatorcontrib>Ishioka, Yasuki</creatorcontrib><creatorcontrib>Shigeishi, Hideo</creatorcontrib><creatorcontrib>Higashikawa, Koichiro</creatorcontrib><creatorcontrib>Kamata, Nobuyuki</creatorcontrib><title>Human papillomavirus-16 in oral squamous cell carcinoma: Clinical correlates and 5-year survival</title><title>British journal of oral & maxillofacial surgery</title><addtitle>Br J Oral Maxillofac Surg</addtitle><description>Abstract We examined 66 oral squamous cell carcinomas (OSCCs) for human papillomavirus-16 (HPV-16) infection to evaluate its prognostic significance. Cox regression analysis of 5-year survival demonstrated that patients without nodal metastasis or with intratumoural HPV-16 showed better prognoses compared with each counterpart. In Kaplan-Meier survival analysis, nodal status but not HPV-16 status was statistically significant. The 5-year survival rate of HPV-16 positive patients without nodal metastasis (94%) was extremely high, compared with that of HPV-16 negative patients with nodal metastasis (25%). These results suggest that HPV-16 status as well as nodal status may provide prognostic significance in patients with OSCC.</description><subject>5-year survival</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>Clinical correlates</subject><subject>Dentistry</subject><subject>Disease-Free Survival</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Human papillomavirus 16 - isolation & purification</subject><subject>Human papillomavirus-16</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Logistic Models</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - virology</subject><subject>Multivariate analysis</subject><subject>Oral squamous cell carcinoma</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Papillomavirus Infections - mortality</subject><subject>Proportional Hazards Models</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0266-4356</issn><issn>1532-1940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkk1r3DAQhkVpabZpf0Gh6NLe7OrDkq1CA2Vpm0Agh7RndVYeg1zZ3kjrhf33lbOGQC856aDnfRmeGULec1ZyxvXnvtz105BKwZguWVUyLl6QDVdSFNxU7CXZMKF1UUmlL8iblHrGmBJcvSYXXNcNz78b8ud6HmCke9j7EKYBjj7OqeCa-pFOEQJNDzMM05yowxCog-j8mLkvdBv86F0m3BQjBjhgojC2VBUnhEjTHI_-COEtedVBSPhufS_J7x_ff22vi9u7nzfbb7eFqypxKIxDg7VpHQA3nRbatFK0Tu6M4sJIp3nttGRaNlxgB0abhiHIruqEcqKp5SX5dO7dx-lhxnSwg0_LzDBiHt_qJjcpzTIoz6CLU0oRO7uPfoB4spzZRazt7aNYu4i1rLJZbE59WOvn3YDtU2Y1mYGPKwApW-kijM6nJ65RmXrkvp45zDKOHqNNzuPosPUR3cG2k39mkKv_8m5dxF88YeqnOY7Zs-U2Ccvs_XIDywkwnddvVC3_AZdQrDg</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Sugiyama, Masaru</creator><creator>Bhawal, Ujjal Kumar</creator><creator>Kawamura, Makoto</creator><creator>Ishioka, Yasuki</creator><creator>Shigeishi, Hideo</creator><creator>Higashikawa, Koichiro</creator><creator>Kamata, Nobuyuki</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Human papillomavirus-16 in oral squamous cell carcinoma: Clinical correlates and 5-year survival</title><author>Sugiyama, Masaru ; Bhawal, Ujjal Kumar ; Kawamura, Makoto ; Ishioka, Yasuki ; Shigeishi, Hideo ; Higashikawa, Koichiro ; Kamata, Nobuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-9ce9e79dcaa19f6269d32dc3b951293c617c63063812efa96980ea3f4f25c2873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>5-year survival</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>Clinical correlates</topic><topic>Dentistry</topic><topic>Disease-Free Survival</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Human papillomavirus 16 - isolation & purification</topic><topic>Human papillomavirus-16</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Logistic Models</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - virology</topic><topic>Multivariate analysis</topic><topic>Oral squamous cell carcinoma</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Papillomavirus Infections - mortality</topic><topic>Proportional Hazards Models</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugiyama, Masaru</creatorcontrib><creatorcontrib>Bhawal, Ujjal Kumar</creatorcontrib><creatorcontrib>Kawamura, Makoto</creatorcontrib><creatorcontrib>Ishioka, Yasuki</creatorcontrib><creatorcontrib>Shigeishi, Hideo</creatorcontrib><creatorcontrib>Higashikawa, Koichiro</creatorcontrib><creatorcontrib>Kamata, Nobuyuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of oral & maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugiyama, Masaru</au><au>Bhawal, Ujjal Kumar</au><au>Kawamura, Makoto</au><au>Ishioka, Yasuki</au><au>Shigeishi, Hideo</au><au>Higashikawa, Koichiro</au><au>Kamata, Nobuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human papillomavirus-16 in oral squamous cell carcinoma: Clinical correlates and 5-year survival</atitle><jtitle>British journal of oral & maxillofacial surgery</jtitle><addtitle>Br J Oral Maxillofac Surg</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>45</volume><issue>2</issue><spage>116</spage><epage>122</epage><pages>116-122</pages><issn>0266-4356</issn><eissn>1532-1940</eissn><coden>BJOSEY</coden><abstract>Abstract We examined 66 oral squamous cell carcinomas (OSCCs) for human papillomavirus-16 (HPV-16) infection to evaluate its prognostic significance. Cox regression analysis of 5-year survival demonstrated that patients without nodal metastasis or with intratumoural HPV-16 showed better prognoses compared with each counterpart. In Kaplan-Meier survival analysis, nodal status but not HPV-16 status was statistically significant. The 5-year survival rate of HPV-16 positive patients without nodal metastasis (94%) was extremely high, compared with that of HPV-16 negative patients with nodal metastasis (25%). These results suggest that HPV-16 status as well as nodal status may provide prognostic significance in patients with OSCC.</abstract><cop>Londonc</cop><pub>Elsevier Ltd</pub><pmid>16781026</pmid><doi>10.1016/j.bjoms.2006.04.012</doi><tpages>7</tpages></addata></record> |
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| subjects | 5-year survival Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - virology Clinical correlates Dentistry Disease-Free Survival DNA, Viral - analysis Female Human papillomavirus 16 - isolation & purification Human papillomavirus-16 Humans Kaplan-Meier Estimate Logistic Models Lymphatic Metastasis Male Medical sciences Middle Aged Mouth Neoplasms - mortality Mouth Neoplasms - virology Multivariate analysis Oral squamous cell carcinoma Otorhinolaryngology. Stomatology Papillomavirus Infections - mortality Proportional Hazards Models Surgery Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Human papillomavirus-16 in oral squamous cell carcinoma: Clinical correlates and 5-year survival |
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