Donors whose blood reacts falsely positive in transfusion microbiology screening assays need not be lost to transfusion

summary Donations that repeatedly react in transfusion microbiology screening assays are usually discarded; with appropriate confirmatory testing on the index and on follow‐up samples, the great majority of these can be shown to be falsely positive. Under carefully controlled conditions, with secure...

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Bibliographic Details
Published in:Transfusion medicine (Oxford, England) England), 2007-02, Vol.17 (1), p.55-59
Main Authors: Moore, M. C., Howell, D. R., Barbara, J. A. J.
Format: Article
Language:English
Subjects:
Adult
Algorithms
Blood Banks - standards
Blood Donors - psychology
Blood Transfusion - statistics & numerical data
Enzyme-Linked Immunosorbent Assay
False Positive Reactions
false reactivity
Female
Humans
Infection - blood
Infection - diagnosis
Infection Control - methods
Infection Control - standards
Male
Practice Guidelines as Topic
Predictive Value of Tests
re-admission
resources
transfusion microbiology
Transfusion Reaction
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Summary:summary Donations that repeatedly react in transfusion microbiology screening assays are usually discarded; with appropriate confirmatory testing on the index and on follow‐up samples, the great majority of these can be shown to be falsely positive. Under carefully controlled conditions, with secure information transfer, these donations, although still reactive in the primary screening assays, can be made available for clinical use after testing and obtaining negative results with alternative assays from a list of assays evaluated as suitable for the release of blood donations. We will describe a generic algorithm that can be applied to all markers.
ISSN:0958-7578
1365-3148
DOI:10.1111/j.1365-3148.2006.00700.x