Bone mineral density in children with cirrhosis

Despite the clinical importance of osteoporosis in individuals with cirrhosis, little is known about it, especially in children. We evaluated the bone mineral density (BMD) and bone mineral content (BMC) of children with cirrhosis. Forty children with cirrhosis (mean age, 10.4 +/- 3.9 years) were in...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastroenterology 2006-09, Vol.41 (9), p.873-877
Main Authors: Uslu, Nuray, Saltik-Temizel, Inci Nur, Demir, Hülya, Usta, Yusuf, Ozen, Hasan, Gürakan, Figen, Yüce, Aysel, Koçak, Nurten
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adolescent
Biopsy
Bone Density - physiology
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Liver Cirrhosis - complications
Liver Cirrhosis - metabolism
Liver Cirrhosis - pathology
Lumbar Vertebrae - diagnostic imaging
Male
Osteoporosis - diagnostic imaging
Osteoporosis - epidemiology
Osteoporosis - etiology
Retrospective Studies
Risk Factors
Severity of Illness Index
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite the clinical importance of osteoporosis in individuals with cirrhosis, little is known about it, especially in children. We evaluated the bone mineral density (BMD) and bone mineral content (BMC) of children with cirrhosis. Forty children with cirrhosis (mean age, 10.4 +/- 3.9 years) were involved. BMD and BMC were measured by dual energy X-ray absorptiometry at lumbar vertebrae 1-4, and the results were compared with those of 62 healthy age- and sex-matched children. The mean lumbar spine BMD of patients with cirrhosis was 0.482 +/- 0.107 g/cm(2) and that of the controls was 0.687 +/- 0.172 g/cm(2) (P < 0.0001). The mean lumbar spine BMC of patients with cirrhosis was 20.008 +/- 8.409 g and that of controls was 32.859 +/- 14.665 g (P < 0.0001). After the confounding variables (weight, height, and pubertal stage) were controlled for, the difference in BMD and BMC values between patients with cirrhosis and healthy controls was significant (0.535 +/- 0.061 g/cm(2) vs 0.653 +/- 0.048 g/cm(2), and 24.515 +/- 5.052 g vs 29.952 +/- 3.971 g, respectively). Because of the significant difference in BMD and BMC values between our patients with cirrhosis and healthy controls, patients with cirrhosis should be evaluated for osteopenia.
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-006-1864-4