Growth in post-viral chronic lung disease

Acute lower respiratory infection due to adenovirus is an important cause of chronic lung disease (CLD) in infants. The objectives of this paper is to describe growth in the height and weight of children with post-viral chronic lung disease (PVCLD) and to relate it with associated variables (invasiv...

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Bibliographic Details
Published in:European journal of pediatrics 2006-12, Vol.165 (12), p.845-849
Main Authors: DEL PINO, Mariana, BAUER, Gabriela, GONZALEZ PENA, Hebe, GRENOVILLE, Mario, LEJARRAGA, Horacio
Format: Article
Language:English
Subjects:
Adenovirus Infections, Human - complications
Adenoviruses
Biological and medical sciences
Body Height - physiology
Body Weight - physiology
Child, Preschool
Chronic Disease
Chronic illnesses
Female
Follow-Up Studies
General aspects
Growth - physiology
Humans
Hypercapnia - physiopathology
Infant
Infections
Logistic Models
Lung diseases
Lung Diseases - physiopathology
Lung Diseases - virology
Male
Medical sciences
Oxygen therapy
Patients
Prospective Studies
Respiratory Tract Infections - complications
Risk Factors
Velocity
Viral infections
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Summary:Acute lower respiratory infection due to adenovirus is an important cause of chronic lung disease (CLD) in infants. The objectives of this paper is to describe growth in the height and weight of children with post-viral chronic lung disease (PVCLD) and to relate it with associated variables (invasive mechanical ventilation, chronic hypercapnia, oxygen therapy at home and steroid treatment). Ninety-nine patients with diagnosis of PVCLD with one or more years of follow-up were included in the study. The median duration of follow-up was 3.10 years. The median age at onset of the disease was 0.50 years. According to the growth in height, there were 48 children with normal growth (Type A) and 50 with slow growth (Type B) followed by catch-up growth (N=45) or normal growth velocity (N=5); only one patient showed persistent slow growth. Chronic hypercapnia was a risk factor significantly associated to slow growth, with odds ratio, OR: 5.03; and 95% confidence interval, CI: 1.83/13.83. Patients with higher weight for height at the end of the slow-growth period showed greater gains in height during the following period (r=0.46). Growth in children with PVCLD is heterogeneous but, in the majority of individual cases, it can be considered satisfactory. Chronic hypercapnia was associated with slow growth.
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-006-0179-z