Controlled immobilization of chondroitin sulfate in polyacrylic acid networks

Novel semi-interpenetrating polymer networks (semi-IPNs) of chondroitin sulfate (ChS) and acrylic acid (AA) were prepared with the aim of obtaining a hydrogel for use as a colon-specific drug carrier. By controlling the concentrations of cross-linking agent, diethylene glycol dimethacrylate (DEGDA),...

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Bibliographic Details
Published in:Journal of biomaterials science. Polymer ed. 2007-01, Vol.18 (1), p.17-34
Main Authors: Huang, Shih-Jer, Wang, Jin-Ming, Tseng, Sun-Chang, Wang, Li-Fang, Chen, Jenn-Shing
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
CHONDROITIN SULFATE
Chondroitin Sulfates - chemistry
CROSS-LINKING DENSITY
Drug Carriers - chemistry
HYDROGEL
Hydrogels
Hydrogen Bonding
Ketoprofen - chemistry
POLYACRYLIC ACID
SEMI-INTERPENETRATING POLYMER NETWORK
Spectroscopy, Fourier Transform Infrared
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Summary:Novel semi-interpenetrating polymer networks (semi-IPNs) of chondroitin sulfate (ChS) and acrylic acid (AA) were prepared with the aim of obtaining a hydrogel for use as a colon-specific drug carrier. By controlling the concentrations of cross-linking agent, diethylene glycol dimethacrylate (DEGDA), as well as the reaction solvent, high swelling percentages were obtained (approx. 1600%). However, the highest sol percent obtained for these hydrogels was approx. 70%, and most of the chondroitin sulfate remained soluble and could be extracted. Therefore, an alternative approach was adopted: methacrylate-grafted ChS (ChSMA) was synthesized and then co-polymerized with acrylic acid (AA) at a molar ratio of 1:5 with various concentrations of AA. The sol content of these ChSMA-AA hydrogels was reduced to approx. 20%, and the cross-linking densities were almost 100-fold higher than those of the semi-IPNs. FT-IR spectra showed that the H-bonding interactions between ChS and PAA and the spectra of the semi-IPNs were similar to that of PAA itself after sol extraction. In contrast, the FT-IR spectra of ChSMA-AA remained intact after sol extraction. Ketoprofen was used as a model drug to test the sustained release behavior of these hydrogels.
ISSN:0920-5063
1568-5624
DOI:10.1163/156856207779146097