Association between obsessive–compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of the serotonin transporter gene

Pharmacological studies indicate a dysregulation of the serotonergic system in obsessive–compulsive disorder (OCD). A variable number tandem repeats (VNTR) polymorphism with three alleles (Stin2.9, Stin2.10, Stin2.12) has been described in intron 2 of the serotonin transporter (5-HTT) gene. This pol...

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Published in:Progress in neuro-psychopharmacology & biological psychiatry 2007-03, Vol.31 (2), p.416-420
Main Authors: Baca-Garcia, Enrique, Vaquero-Lorenzo, Concepcion, Diaz-Hernandez, Montserrat, Rodriguez-Salgado, Beatriz, Dolengevich-Segal, Helen, Arrojo-Romero, Manuel, Botillo-Martin, Carlota, Ceverino, Antonio, Piqueras, Jose Fernandez, Perez-Rodriguez, M. Mercedes, Saiz-Ruiz, Jeronimo
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Alleles
Anxiety disorders. Neuroses
Biological and medical sciences
Gene Frequency
Genetic polymorphism
Genetic Predisposition to Disease
Humans
Intron 2
Introns
Medical sciences
Minisatellite Repeats - genetics
Neuropharmacology
Obsessive-Compulsive Disorder - genetics
Obsessive-compulsive disorders
Obsessive–compulsive disorder
Pharmacology. Drug treatments
Polymorphism, Genetic - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serotonin Plasma Membrane Transport Proteins - genetics
Serotonin transporter
Variable number tandem repeats
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Summary:Pharmacological studies indicate a dysregulation of the serotonergic system in obsessive–compulsive disorder (OCD). A variable number tandem repeats (VNTR) polymorphism with three alleles (Stin2.9, Stin2.10, Stin2.12) has been described in intron 2 of the serotonin transporter (5-HTT) gene. This polymorphism has been associated with unipolar depression, bipolar disorder, schizophrenia, and anxiety disorders including OCD. The association between OCD and the polymorphism is examined in 97 OCD patients, 578 psychiatric controls and 406 healthy controls, all Spanish Caucasians. Genotype frequencies for the polymorphism were significantly different in OCD patients, psychiatric patients and controls. There was a significant excess of 12/12 and 12/10 genotypes in OCD patients compared to psychiatric patients and controls. Our results indicate a possible association between the Stin2.12 allele of the VNTR polymorphism and OCD.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2006.10.016