Multifocal rapidly involuting congenital hemangioma: A link to chorangioma

Common infantile hemangioma is intriguing because of its variable presentation, rapid postnatal growth and slow regression in childhood. Interest in this tumor has increased with the recognition that it can be associated with structural anomalies in the craniofacial and ventral‐caudal regions. The p...

Full description

Saved in:
Bibliographic Details
Published in:American journal of medical genetics. Part A 2007-12, Vol.143A (24), p.3038-3046
Main Authors: Mulliken, J.B., Bischoff, J., Kozakewich, H.P.W.
Format: Article
Language:English
Subjects:
Angiomatosis
Biological and medical sciences
chorangioma
congenital hemangioma
Hemangioma - diagnosis
Hemangioma, Capillary - diagnosis
Humans
Infant
Male
Medical genetics
Medical sciences
Phenotype
Placenta - pathology
Regression Analysis
Treatment Outcome
Umbilical Cord - pathology
Vascular Malformations - diagnosis
Vascular Neoplasms - diagnosis
Vascular Neoplasms - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Common infantile hemangioma is intriguing because of its variable presentation, rapid postnatal growth and slow regression in childhood. Interest in this tumor has increased with the recognition that it can be associated with structural anomalies in the craniofacial and ventral‐caudal regions. The phenotype has expanded by characterization of rare vascular tumors that arise in the fetus and manifest at birth as rapidly involuting congenital hemangioma (RICH) or non‐involuting congenital hemangioma (NICH). We describe a boy born with three RICH on the abdominal wall; one extended into the base of the umbilical cord. Two weeks later a small, infantile hemangioma arose on his neck. This patient stimulated a review of what is known about placental vascular tumors and their possible relationship to fetal and infantile hemangiomas. We suggest that chorangioma and umbilical cord hemangioma are clinically and histopathologically similar to cutaneous and hepatic RICH. These placental vascular tumors can also occur in conjunction with solitary and multiple infantile hemangiomas. © 2007 Wiley‐Liss, Inc.
ISSN:1552-4825
1552-4833
DOI:10.1002/ajmg.a.31964