Long terminal repeats of porcine endogenous retroviruses in Sus scrofa

Using PCR, sequencing, and bioinformatic approaches with the genomic DNAs of Korean pigs (domestic, wild, and hybrid with Yorkshire), twelve solitary PERV long terminal repeat elements were identified and analyzed. Structure analysis of the LTR elements indicated that they have different repeat sequ...

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Bibliographic Details
Published in:Archives of virology 2007-12, Vol.152 (12), p.2271-2276
Main Authors: HUH, J.-W, CHO, B.-W, KIM, D.-S, HA, H.-S, NOH, Y.-N, YI, J.-M, LEE, W.-H, KIM, H.-S
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Bioinformatics
Biological and medical sciences
Cloning
Computational Biology - methods
Endogenous Retroviruses - genetics
Fundamental and applied biological sciences. Psychology
Genomes
Hogs
Korea
Mice
Microbiology
Miscellaneous
Molecular Sequence Data
Polymerase Chain Reaction - methods
Sequence Analysis, DNA
Sus scrofa
Sus scrofa - virology
Terminal Repeat Sequences - genetics
Virology
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Summary:Using PCR, sequencing, and bioinformatic approaches with the genomic DNAs of Korean pigs (domestic, wild, and hybrid with Yorkshire), twelve solitary PERV long terminal repeat elements were identified and analyzed. Structure analysis of the LTR elements indicated that they have different repeat sequences in the U3 region. The PERV-A6-KWP1 and -KWP2 elements bear seven and eight 39-bp repeats, respectively. The R region of the PERV LTR elements was highly conserved in pig and mouse genomes, suggesting that they seem to have originated from a common exogenous viral element and then evolved independently throughout the course of mammalian evolution.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-007-1049-3