Is high-grade prostatic intraepithelial neoplasia on needle biopsy different in an Asian population: A clinicopathologic study performed in Singapore

To evaluate the incidence, pathologic findings, and follow-up of high-grade prostatic intraepithelial neoplasia (HGPIN) in a series of prostate core biopsies from Singaporean men. We studied isolated HGPIN diagnosed on prostate core biopsies and the incidence of cancer discovered in men who had unde...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2006-10, Vol.68 (4), p.800-803
Main Authors: Tan, Puay Hoon, Tan, Hong Wui, Tan, Yen, Lim, Chay Ngee, Cheng, Christopher, Epstein, Jonathan I.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Asian Continental Ancestry Group
Biological and medical sciences
Biopsy, Needle
Follow-Up Studies
Humans
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Prostatectomy
Prostatic Intraepithelial Neoplasia - epidemiology
Prostatic Intraepithelial Neoplasia - ethnology
Prostatic Intraepithelial Neoplasia - pathology
Prostatic Intraepithelial Neoplasia - surgery
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - ethnology
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Reoperation
Retrospective Studies
Singapore
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:To evaluate the incidence, pathologic findings, and follow-up of high-grade prostatic intraepithelial neoplasia (HGPIN) in a series of prostate core biopsies from Singaporean men. We studied isolated HGPIN diagnosed on prostate core biopsies and the incidence of cancer discovered in men who had undergone repeat biopsies from 1999 to 2003 at the Department of Pathology, Singapore General Hospital. Of 1219 men undergoing prostate needle biopsy, 56 (4.6%) had isolated HGPIN. Most cases affected a single prostate core (44 cases, 78.6%). Twenty-nine men (51.8%) underwent repeat biopsies. Cancer was discovered in 7 (24.1%) of the 29 men within two repeat biopsies. The incidence of isolated HGPIN on prostate needle core biopsies in Asian men, as well as the likelihood of subsequent cancer detection, are comparable to the rates reported for Western populations. The relatively low yield of cancer detection on repeat biopsy supports the need to re-evaluate recommendations for rebiopsy strategies.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2006.04.026