An Inverse Relationship Between Perceived Harm and Participation Willingness in Schizophrenia Research Protocols

Objective: This study attempted to clarify how people with schizophrenia evaluate the potential harm associated with various research-related procedures and how these assessments relate to participation willingness. Method: The authors conducted a semistructured interview among participants with sch...

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Bibliographic Details
Published in:The American journal of psychiatry 2006-11, Vol.163 (11), p.2002-2004
Main Authors: Roberts, Laura Weiss, Hammond, Katherine Green, Hoop, Jinger
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Attitude to Health
Biological and medical sciences
Clinical Protocols - standards
Decision Making
Ethics, Research
Female
Human subjects
Humans
Informed consent
Male
Medical sciences
Patient Participation
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Research Design - standards
Research Subjects - psychology
Schizophrenia
Schizophrenia - diagnosis
Schizophrenic Psychology
Studies
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Summary:Objective: This study attempted to clarify how people with schizophrenia evaluate the potential harm associated with various research-related procedures and how these assessments relate to participation willingness. Method: The authors conducted a semistructured interview among participants with schizophrenia. Results: Sixty participants with schizophrenia rated four procedures as harmful (e.g., symptom induction), five procedures as moderately harmful (e.g., being given a placebo), and six procedures as not harmful (e.g., undergoing a physical examination). Rated willingness to participate was inversely related to the participants' perceptions of harmfulness for all procedures. Conclusions: In this study, people living with schizophrenia perceived different research procedures as posing different levels of possible harm. Potential harm appears to be an important consideration in protocol enrollment decisions. This work reaffirms the value of clarifying the strengths of seriously ill people who may choose to participate in research.
ISSN:0002-953X
1535-7228
DOI:10.1176/ajp.2006.163.11.2002