Influence of Institutionalization on Time to HIV Disease Progression in a Cohort of Romanian Children and Teens

The purpose of this work was to investigate the effect of institutionalization on death and CD4 decline in a cohort of 325 HIV-infected Romanian children. A retrospective database analysis was conducted. Data from a nearly 3-year period were examined with Kaplan-Meier survival analysis and Cox regre...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2007-12, Vol.120 (6), p.e1476-e1480
Main Authors: Ferris, Margaret, Burau, Keith, Constantin, Ana Maria, Mihale, Stefania, Murray, Nancy, Preda, Alina, Ross, Michael, Kline, Mark W
Format: Article
Language:English
Subjects:
Adolescent
Child
Children & youth
Death & dying
Disease Progression
Female
Glycoproteins
HIV
HIV Infections - mortality
HIV Infections - therapy
Human immunodeficiency virus
Humans
Institutionalization - statistics & numerical data
Male
Medical treatment
Pediatrics
Regression analysis
Romania
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Summary:The purpose of this work was to investigate the effect of institutionalization on death and CD4 decline in a cohort of 325 HIV-infected Romanian children. A retrospective database analysis was conducted. Data from a nearly 3-year period were examined with Kaplan-Meier survival analysis and Cox regression analysis models. Subjects all received primary and HIV specialty care and treatment at the Romanian American Children's Center in Constanta, Romania. Children in one group resided with their biological families and the other children resided in "family home"-style institutions. There was no difference between groups for death during the follow-up period, although there was a trend for survival advantage for children in institutional care. There was no statistically significant difference between the study groups in terms of CD4 decline, although there was a trend toward greater decline among children who resided with their biological families. Children with their biological families were more likely to experience disease progression through either death or CD4 decline than were children in institutions. The family home-style institution may prove to be a replicable model for the safe and appropriate care of HIV-infected orphaned and abandoned children and teens.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2006-1503