Laboratory Model of Tissue Adhesive (2-Octyl Cyanoacrylate) in Sealing Clear Corneal Cataract Wounds

To determine the efficacy of a tissue adhesive (2-octyl cyanoacrylate with parabens; Liquid Bandage, Johnson & Johnson, Skillman, New Jersey) in sealing clear corneal cataract wounds. Laboratory investigation. Seven human donor globes were prepared for Miyake video microscopy. A 3.0-mm clear cor...

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Bibliographic Details
Published in:American journal of ophthalmology 2005-12, Vol.140 (6), p.1039-1043
Main Authors: Ritterband, David C., Meskin, Seth W., Shapiro, Daniel E., Kusmierczyk, Jaroslaw, Seedor, John A., Koplin, Richard S.
Format: Article
Language:English
Subjects:
Anterior Chamber - metabolism
Biological and medical sciences
Body Fluids - metabolism
Bond strength
Carbon - metabolism
Cataract Extraction - methods
Cataracts
Cellulose
Cornea - metabolism
Cornea - surgery
Cyanoacrylates - therapeutic use
Eye surgery
Humans
Ink
Intraocular Pressure - physiology
Laboratories
Lens diseases
Medical sciences
Miscellaneous
Models, Biological
Ophthalmology
Polymerization
Surgery
Tissue Adhesives - therapeutic use
Tissue Donors
Wound healing
Wound Healing - drug effects
Wound Healing - physiology
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Summary:To determine the efficacy of a tissue adhesive (2-octyl cyanoacrylate with parabens; Liquid Bandage, Johnson & Johnson, Skillman, New Jersey) in sealing clear corneal cataract wounds. Laboratory investigation. Seven human donor globes were prepared for Miyake video microscopy. A 3.0-mm clear corneal incision was created. A transscleral cannula was inserted and connected to a bottle of saline. The bottle height was varied to alter intraocular pressure. Droplets of India ink were placed on the wound. Main outcome measure was any influx of India ink into the anterior chamber as viewed through the Miyake system with intraocular pressure (IOP) fluctuation or with manual pressure. If India ink was present in the eye, it was irrigated out, and the experiment was repeated with IOP fluctuation and manual pressure after the application of 2-octyl cyanoacrylate to the wound. One eye demonstrated the presence of India ink inside the eye on IOP reduction to
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2005.06.055