Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase

Treatment with peptides based on the complementarity determining regions (CDR) of murine and human monoclonal anti-DNA antibodies that bear the common idiotype, 16/6 Id, ameliorates disease manifestations of mice with either induced or spontaneous SLE. Aberrant expression and function of the p21Ras/...

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Bibliographic Details
Published in:	Clinical Immunology 2005-12, Vol.117 (3), p.262-270
Main Authors:	Rapoport, Micha J., Sharabi, Amir, Aharoni, Dorit, Bloch, Olga, Zinger, Heidy, Dayan, Molly, Mozes, Edna
Format:	Article
Language:	English
Subjects:	(NZBxNZW)F1 mice Animals Apoptosis Apoptosis - immunology Autoantibodies - drug effects Autoantibodies - immunology Autoimmune Diseases - genetics Autoimmune Diseases - immunology Biological and medical sciences CDR-based peptides Complementarity Determining Regions - therapeutic use Crosses, Genetic Disease Models, Animal Down-Regulation Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immunization Immunomodulation Immunopathology JNK kinase Lupus Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - immunology MAP Kinase Kinase 4 - metabolism Medical sciences Mice Mice, Inbred NZB p21Ras pathway Peptide Fragments - therapeutic use Proto-Oncogene Proteins p21(ras) - metabolism Signal Transduction T-Lymphocytes - cytology T-Lymphocytes - immunology
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