Opa Typing of Neisseria gonorrhoeae Strains Isolated From Patients Attending Sexually Transmitted Disease Clinics in China

Background: Gonorrhoea has been one of the most common sexually transmitted diseases (STDs) in China. A clear understanding of its transmission dynamics is important in formulating prevention and control measures. Goal: To investigate the distribution of opa types in patients attending at STD clinic...

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Bibliographic Details
Published in:Sexually transmitted diseases 2007-12, Vol.34 (12), p.967-973
Main Authors: CHEN, QIANG, YIN, YUE-PING, DAI, XIU-QIN, YU, YAN-HUA, WANG, HONG-CHUN, ZHU, BANG-YONG, GAO, XING, CHEN, XIANG-SHENG
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Ambulatory Care Facilities
Anti-Bacterial Agents - pharmacology
Bacterial Outer Membrane Proteins - genetics
Bacterial Typing Techniques
Biological and medical sciences
Child
China - epidemiology
Disease control
Disease prevention
Disease transmission
DNA, Bacterial - analysis
DNA, Bacterial - isolation & purification
Epidemiology. Vaccinations
Female
General aspects
Genotype
Gonorrhea
Gonorrhea - epidemiology
Gonorrhea - microbiology
Gonorrhea - prevention & control
Gonorrhea - transmission
Human infectious diseases. Experimental studies and models
Humans
Infectious diseases
Male
Medical sciences
Microbial Sensitivity Tests
Middle Aged
Neisseria gonorrhoeae
Neisseria gonorrhoeae - classification
Neisseria gonorrhoeae - genetics
Neisseria gonorrhoeae - isolation & purification
Sexually Transmitted Diseases - prevention & control
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Summary:Background: Gonorrhoea has been one of the most common sexually transmitted diseases (STDs) in China. A clear understanding of its transmission dynamics is important in formulating prevention and control measures. Goal: To investigate the distribution of opa types in patients attending at STD clinics in China and to evaluate the concordance between epidemiologic data and opa-typing results. Study Design: Opa typing was conducted for 330 Neisseria gonorrhoeae strains isolated from the patients at 4 STDs clinics in China, and the epidemiologic data were collected as well. Results: A total of 309 opa types were detected from the 330 isolates. Two hundred ninety-two opa types were unique, and 17 opa types were found in more than 1 patient. Opa typing confirmed all 9 sexual links that were revealed by epidemiologic information and further identified 9 opa clusters and 8 similar pairs. Conclusions: Opa typing is a discriminatory tool that can be used in epidemiologic studies on gonococcal infections. This technique is more powerful than epidemiologic data to identify sexual links and improve our understanding of the transmission dynamics of gonorrhoea.
ISSN:0148-5717
1537-4521
DOI:10.1097/OLQ.0b013e3181132b4d