Mobile DNA elements: controlling transposition with ATP-dependent molecular switches

Nucleotide-binding proteins are often used as molecular switches to control the assembly or activity of macromolecular machines. Recent work has revealed that such molecular switches also regulate the spread of some mobile DNA elements. Bacteriophage Mu and the bacterial transposon Tn7 each use an A...

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Bibliographic Details
Published in:Trends in Biochemical Sciences 1998-12, Vol.23 (12), p.486-490
Main Authors: Stellwagen, Anne E., Craig, Nancy L.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Bacteriophage mu
DNA binding
DNA Transposable Elements
EF-Tu
Peptide Elongation Factor Tu - metabolism
Phage Mu
Ras
ras Proteins - metabolism
Tn7
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Summary:Nucleotide-binding proteins are often used as molecular switches to control the assembly or activity of macromolecular machines. Recent work has revealed that such molecular switches also regulate the spread of some mobile DNA elements. Bacteriophage Mu and the bacterial transposon Tn7 each use an ATP-dependent molecular switch to select a new site for insertion and to coordinate the assembly of the transposition machinery at that site. Strong parallels between these ATP-dependent transposition proteins and other well-characterized molecular switches, such as Ras and EF-Tu, have emerged.
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(98)01325-5