Gastrointestinal hormones as potential adjuvant treatment of exocrine pancreatic adenocarcinoma

Gastrointestinal hormones and their antagonists can alter the growth of pancreatic adenocarcinoma in vitro and in vivo. The potential clinical benefit of this approach deserves further study. Epithelial cell growth is normally under hormonal control. Hormones also affect the growth of many epithelia...

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Bibliographic Details
Published in:International journal of pancreatology 1998-12, Vol.24 (3), p.169-180
Main Authors: FISHER, W. E, MUSCARELLA, P, BOROS, L. G, SCHIRMER, W. J
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - pathology
Animals
Biological and medical sciences
Chemotherapy, Adjuvant
Digestive system
Gastrointestinal Hormones - adverse effects
Gastrointestinal Hormones - therapeutic use
Growth Inhibitors - therapeutic use
Humans
Medical sciences
Neoplasms, Hormone-Dependent - drug therapy
Neoplasms, Hormone-Dependent - pathology
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - pathology
Pharmacology. Drug treatments
Tumor Cells, Cultured
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Summary:Gastrointestinal hormones and their antagonists can alter the growth of pancreatic adenocarcinoma in vitro and in vivo. The potential clinical benefit of this approach deserves further study. Epithelial cell growth is normally under hormonal control. Hormones also affect the growth of many epithelial cancers, and this fact is used to modify tumor growth. Pancreatic epithelial cell growth is under the influence of gastrointestinal hormones. This article reviews experiments designed to determine the effect of gastrointestinal hormones on the growth of pancreatic adenocarcinoma. Eighty-eight articles were identified from a Medline search using the terms pancreatic adenocarcinoma and the individual names of gastrointestinal hormones. The experimental design and results of these studies are reviewed. In general, somatostatin, vasoactive intestinal polypeptide, pancreatic polypeptide, and pancreastatin inhibit pancreatic adenocarcinoma growth. Cholecystokinin, secretin, bombesin, gastrin, EGF, TGF-alpha, insulin, and IGF-1 have a growth-promoting effect.
ISSN:0169-4197
2363-5134
DOI:10.1007/BF02788419