Synthesis and hybridization property of an oligonucleotide analog containing A 1′,3′-DI- O-methylene-α- D-fructose backbone

Hydrogen phosphonate monomers of T (thymine) and C m (5-methylcytosine) bearing a 1′,3′-di- O-methylene-α- D-fructose sugar moiety were synthesized and incorporated into an oligonucleotide. Hybridization studies by thermal denaturation experiment indicated that this oligonucleotide did not form a du...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-11, Vol.8 (21), p.3049-3052
Main Authors: Zou, Ruiming, Matteucci, Mark D.
Format: Article
Language:English
Subjects:
Carbohydrates. Nucleosides and nucleotides
Chemistry
Exact sciences and technology
Fructose
Nucleic Acid Hybridization
Nucleosides, nucleotides and oligonucleotides
Oligonucleotides, Antisense - chemical synthesis
Oligonucleotides, Antisense - chemistry
Organic chemistry
Preparations and properties
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Summary:Hydrogen phosphonate monomers of T (thymine) and C m (5-methylcytosine) bearing a 1′,3′-di- O-methylene-α- D-fructose sugar moiety were synthesized and incorporated into an oligonucleotide. Hybridization studies by thermal denaturation experiment indicated that this oligonucleotide did not form a duplex with the complementary RNA target.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00566-6