A T1083C polymorphism in the human adenosine A2a receptor gene is not associated with essential hypertension

The adenosine A2a receptor (A2aAR) gene is thought to be involved in essential hypertension because adenosine elicits vasodilation and decreases arterial blood pressure via this receptor, and because disruption of the A2aAR gene increases blood pressure in mice. Therefore, using a restriction fragme...

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Bibliographic Details
Published in:American journal of hypertension 1998-12, Vol.11 (12), p.1492-1494
Main Authors: Soma, Masayoshi, Nakayama, Tomohiro, Satoh, Mikano, Uwabo, Jiro, Rahmutula, Dolkun, Takahashi, Yukie, Fukuda, Noboru, Watanabe, Yoshiyasu, Izumi, Yoichi, Kanmatsuse, Katsuo
Format: Article
Language:English
Subjects:
adenosine A2a receptor
Adult
Aged
Alleles
Arterial hypertension. Arterial hypotension
Association study
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
essential hypertension
Female
genetics
Genotype
Humans
Hypertension - genetics
Male
Medical sciences
Middle Aged
Polymorphism, Restriction Fragment Length
Receptors, Purinergic P1 - genetics
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Summary:The adenosine A2a receptor (A2aAR) gene is thought to be involved in essential hypertension because adenosine elicits vasodilation and decreases arterial blood pressure via this receptor, and because disruption of the A2aAR gene increases blood pressure in mice. Therefore, using a restriction fragment length polymorphism (RFLP) of the A2aAR gene, we performed an association study in patients with essential hypertension. One hundred forty-two patients with essential hypertension and 142 age-matched subjects with normal blood pressure were studied. Polymerase chain reaction (PCR) was applied to amplify the T1083C polymorphic site in the A2aAR gene, and restriction analysis of the PCR product was employed to score the T and C alleles. Overall distributions of allele frequencies in the two groups were not significantly different. Thus, the alleles detected by this RFLP polymorphism in the A2aAR gene are not associated with essential hypertension.
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/S0895-7061(98)00166-6