Expression of the low affinity neurotrophin receptor, P75NGFR, in the rat forebrain, following unilateral bulbectomy

It has been hypothesized that the main olfactory bulb, with its relatively rich source of neurotrophins, may provide trophic support for neurons that project to the bulb. We monitored expression of the common, low affinity receptor for neurotrophins, p75NGFR, in the olfactory bulb and basal forebrai...

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Bibliographic Details
Published in:International journal of developmental neuroscience 1998-10, Vol.16 (6), p.527-538
Main Authors: Turner, Christopher P., Perez‐polo, J.Regino
Format: Article
Language:English
Subjects:
Animals
Brain Chemistry - physiology
Functional Laterality - physiology
Image Processing, Computer-Assisted
lesion
Male
nerve growth factor
Nerve Regeneration - physiology
olfactory
Olfactory Bulb - chemistry
Olfactory Bulb - cytology
Olfactory Bulb - surgery
Prosencephalon - chemistry
Prosencephalon - cytology
Rats
Rats, Sprague-Dawley
Receptor, Nerve Growth Factor
Receptors, Nerve Growth Factor - analysis
Receptors, Nerve Growth Factor - biosynthesis
regeneration
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Summary:It has been hypothesized that the main olfactory bulb, with its relatively rich source of neurotrophins, may provide trophic support for neurons that project to the bulb. We monitored expression of the common, low affinity receptor for neurotrophins, p75NGFR, in the olfactory bulb and basal forebrain of unilaterally bulbectomized and sham‐treated rats, 1–16 weeks post‐surgery, using the monoclonal antibody MAb192. An induction of p75NGFR‐immunoreactivity was observed in both the glomerular and olfactory nerve layers of the right, contralateral main olfactory bulb of lesioned animals. The naturally occurring regeneration taking place in the olfactory neuroepithelium is known to be altered by olfactory bulbectomy, with subsequent changes in the sensory input to the remaining bulb. These changes in expression of p75NGFR in the olfactory bulb support the hypothesis we have developed in previous papers, that changes in the extent of the peripheral input from the olfactory neuroepithelium to the main olfactory bulb regulate p75NGFR expression in both the glomerular and the olfactory nerve layers. Expression of p75NGFR in the basal forebrain of bulbectomized animals was found to be no different than sham‐treated controls and does not support the hypothesis that the olfactory bulb provides trophic support to this region of the central nervous system.
ISSN:0736-5748
1873-474X
DOI:10.1016/S0736-5748(98)00016-1