Hepatic venous pressure gradient as a predictor of fibrosis in chronic liver disease because of hepatitis B virus

Background: Liver biopsy has been considered to be a gold standard for assessing hepatic fibrosis. Sample variability, interobserver variability and step‐wise evaluation limit its use. Hepatic venous pressure gradient (HVPG) correlates with hepatic fibrosis in chronic liver disease (CLD) because of...

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Bibliographic Details
Published in:Liver international 2008-05, Vol.28 (5), p.690-698
Main Authors: Kumar, Manoj, Kumar, Ashish, Hissar, Syed, Jain, Pankaj, Rastogi, Archana, Kumar, Deepak, Sakhuja, Puja, Sarin, Shiv K.
Format: Article
Language:English
Subjects:
Adult
chronic liver disease
Female
fibrosis
hepatic vein pressure gradient
Hepatic Veins - physiology
hepatitis B
Hepatitis B - complications
Hepatitis B - pathology
Humans
HVPG
Liver - pathology
Liver Cirrhosis - etiology
Liver Cirrhosis - pathology
Male
Middle Aged
Portal Pressure - physiology
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Summary:Background: Liver biopsy has been considered to be a gold standard for assessing hepatic fibrosis. Sample variability, interobserver variability and step‐wise evaluation limit its use. Hepatic venous pressure gradient (HVPG) correlates with hepatic fibrosis in chronic liver disease (CLD) because of hepatitis C. Aim: To evaluate the utility of HVPG for assessing hepatic fibrosis in patients with hepatitis B virus (HBV)‐related CLD. Patients and Methods: Sixty‐one patients with HBV‐related CLD who underwent both liver biopsy and hepatic haemodynamic studies were studied. Results: Forty‐nine (80.3%) patients had clinically significant portal hypertension (PHT) (HVPG≥10 mmHg), 39 (63.9%) severe PHT (i.e. HVPG≥12 mmHg), six (9.8%) HVPG≤5 mmHg and another six (9.8%) had preclinical PHT (i.e. HVPG>5 but
ISSN:1478-3223
1478-3231
DOI:10.1111/j.1478-3231.2008.01711.x