Nutritional level and energetic source are determinants of elevated circulatory lipohydroperoxide concentration

Dietary energetic impact on oxidative stress is incompletely understood. Therefore, effects of diets on oxidative stress were studied using a crossover block design. In Expt 1, intake of metabolizable energy (ME) was restricted or ad libitum. In Expt 2, isoenergetic and isonitrogenic diets were fed,...

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Bibliographic Details
Published in:British journal of nutrition 2008-06, Vol.99 (6), p.1255-1265
Main Authors: Löhrke, B., Derno, M., Hammon, H., Metges, C., Melcher, J., Viergutz, T., Jentsch, W., Zühlke, H.
Format: Article
Language:English
Subjects:
Acute oxidative stress
animal models
Animal Nutritional Physiological Phenomena
Animals
Biological and medical sciences
Biomarkers - blood
blood chemistry
Cattle
Cholesterol - blood
Cromakalim
Diet
Dietary Carbohydrates - administration & dosage
Dietary Fats - administration & dosage
dietary nutrient sources
Energy Intake
Energy Metabolism
Energy-dense diet
experimental diets
fatty acids
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Gas exchange
Heart rate
Heart Rate - drug effects
isoenergetic diets
isonitrogenic diets
lipid metabolism
Lipid Peroxides - blood
Lipid-enriched diet
Lipids
lipohydroperoxides
Male
metabolic studies
metabolizable energy
Models, Animal
Nitric oxide
Nitric Oxide Synthase Type III - blood
Nutritional Status
Oxidative Stress
Oxidizing agents
Parasympatholytics
Pulmonary Gas Exchange - drug effects
Triglycerides - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Dietary energetic impact on oxidative stress is incompletely understood. Therefore, effects of diets on oxidative stress were studied using a crossover block design. In Expt 1, intake of metabolizable energy (ME) was restricted or ad libitum. In Expt 2, isoenergetic and isonitrogenic diets were fed, replacing carbohydrate energy by energy of fatty acids. Circulatory lipohydroperoxides (LOOH), markers of acute oxidative stress, were expressed absolutely and in terms of cholesterol or TAG levels. In Expt 1, plasma (jugularis vein) LOOH was assayed in combination with whole-body oxidative metabolism using gas exchange and heart rate (HR) during feeding periods and at rest. In Expt 2, LOOH was assayed in plasma from portal and a large udder vein and a mesenteric artery. In Expt 1, intake increased VO2, HR and LOOH following overnight fast with higher values (P 
ISSN:0007-1145
1475-2662
DOI:10.1017/S000711450886240X