Genome-wide Scan Finds Suggestive Caries Loci

Here we report the first genome-wide scan performed for caries. Evidence from twin studies suggests a genetic component to caries. We aimed to identify genetic factors contributing to caries in a population similarly influenced by confounding factors, such as diet, oral hygiene habits, fluoride expo...

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Bibliographic Details
Published in:Journal of dental research 2008-05, Vol.87 (5), p.435-439
Main Authors: Vieira, A.R., Marazita, M.L., Goldstein-McHenry, T.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
Dental Caries - genetics
Dentistry
DMF Index
Genetic Linkage
Genetic Predisposition to Disease - genetics
Genome, Human - genetics
Humans
Lod Score
Middle Aged
Pedigree
Philippines
Statistics, Nonparametric
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Summary:Here we report the first genome-wide scan performed for caries. Evidence from twin studies suggests a genetic component to caries. We aimed to identify genetic factors contributing to caries in a population similarly influenced by confounding factors, such as diet, oral hygiene habits, fluoride exposure, and access to dental care. Forty-six families with similar cultural and behavioral habits, and living in the Philippines, were studied, and genome-wide genotype data and DMFT (Decayed, Missing due to caries, Filled Teeth) scores were evaluated. Suggestive loci logarithmic odds (LOD) scores above 2.0 or non-parametric p-values below 0.0009) were found for low caries susceptibility (5q13.3, 14q11.2, and Xq27.1) and high caries susceptibility (13q31.1 and 14q24.3). Genes that may be related to saliva flow and diet preferences are proposed as possible candidates. A protective locus for caries in the X chromosome may explain the gender differences seen in caries frequency.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910808700506