Treating the Physical Symptoms of Depression With Second-Generation Antidepressants: A Systematic Review and Metaanalysis

Background Approximately two-thirds of patients with depression experience physical pain symptoms. Coexisting pain complicates the treatment of depression and is associated with worse depression outcomes. Objective The authors reviewed the effect of newer antidepressants on pain in patients with dep...

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Published in:Psychosomatics (Washington, D.C.) D.C.), 2008-05, Vol.49 (3), p.191-198
Main Authors: Krebs, Erin E., M.D., M.P.H, Gaynes, Bradley N., M.D., M.P.H, Gartlehner, Gerald, M.D., M.P.H, Hansen, Richard A., Ph.D., R.Ph, Thieda, Patricia, M.A, Morgan, Laura C., M.A., M.P.H, DeVeaugh-Geiss, Angela, M.S, Lohr, Kathleen N., Ph.D
Format: Article
Language:English
Subjects:
Antidepressive Agents, Second-Generation - therapeutic use
Biological and medical sciences
Depression - drug therapy
Depression - epidemiology
Depression - physiopathology
Duloxetine Hydrochloride
Health Status
Humans
Internal Medicine
Medical sciences
Neuropharmacology
Pain - diagnosis
Pain - epidemiology
Pain Measurement
Paroxetine - therapeutic use
Pharmacology. Drug treatments
Psychiatry
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Systematic review
Thiophenes - therapeutic use
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Summary:Background Approximately two-thirds of patients with depression experience physical pain symptoms. Coexisting pain complicates the treatment of depression and is associated with worse depression outcomes. Objective The authors reviewed the effect of newer antidepressants on pain in patients with depression. Method The authors searched systematically for trials of second-generation antidepressants that enrolled depression patients and reported pain outcomes, pooling changes on the pain visual-analog scale (VAS), using random-effects models. Results Eight trials were eligible. Pooled analysis of head-to-head trials showed no difference in VAS between duloxetine and paroxetine. Both drugs were superior to placebo. Conclusion The authors found insufficient evidence to support the choice of one second-generation antidepressant over another in patients with pain accompanying depression.
ISSN:0033-3182
1545-7206
DOI:10.1176/appi.psy.49.3.191