Essential value of cocaine and food in rats: tests of the exponential model of demand

• Published in: Psychopharmacologia 2008-06, Vol.198 (2), p.221-229
• Main Authors: Christensen, Chesley J., Silberberg, Alan, Hursh, Steven R., Huntsberry, Mary E., Riley, Anthony L.
• Format: Article
• Language: English
• Subjects: Animal behavior; Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Body Weight - physiology; Cocaine; Cocaine - pharmacology; Conditioning, Operant - drug effects; Demand analysis; Drug addiction; Food; Hunger - physiology; Infusions, Intravenous; Male; Medical sciences; Neuropharmacology; Neurosciences; Original Investigation; Pharmacology. Drug treatments; Pharmacology/Toxicology; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Long-Evans; Reinforcement (Psychology); Rodents
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/s00213-008-1120-0

Rationale To provide a prospective test of the predictive adequacy of the exponential model of demand (Hursh and Silberberg, Psych Rev 115(1):186–198, 2008). Objectives In Experiment 1, to measure the ‘ essential value ’ (the propensity to defend consumption with changes in price) of cocaine and food in a demand analysis (functional relation between price and consumption) by means of the exponential model; in Experiment 2, to test whether the model’s systematic underestimation of cocaine consumption in Experiment 1 was due to weight loss; and in Experiment 3, to evaluate the effects of cocaine on the essential value of food. Materials and methods In Experiment 1, demand curves for food and cocaine were determined by measuring consumption of these goods in a multiple schedule over a range of fixed ratios; in Experiment 2, a demand curve for only cocaine was determined; and in Experiment 3, demand for food was determined in the absence of cocaine. Results In Experiment 1, the exponential equation accommodated high portions of variance for both curves, but systematically underestimated cocaine demand; in Experiment 2, this predictive underestimation of the equation was eliminated; and in Experiment 3, the essential value of food was greater than in Experiment 1. Conclusions The exponential model of demand accommodated the data variance for all cocaine and food demand curves. Compared to food, cocaine is a good of lower essential value .