Submaximal exercise in the cold: does cooling potentiate the development of muscle injuries in the rat?

To test the effect of low ambient temperature on muscular strain and possible development of muscle injuries, male Sprague-Dawley rats ( n=35) were exercised at a speed of 15 m min −1 on a treadmill at a 6° inclination for 1.5 h in a warm (22°C) or a cold (−10°C) environment. Blood and tissue sample...

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Bibliographic Details
Published in:Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 1998-11, Vol.121 (3), p.273-278
Main Authors: Mäkinen, Tiina M, Rintamäki, Hannu, Karpakka, Jarmo, Komulainen, Jyrki, Hissa, Raimo
Format: Article
Language:English
Subjects:
Animals
Cold
Cold Climate - adverse effects
Creatine Kinase - blood
Epinephrine - blood
Glucuronidase - metabolism
Hydrocortisone - blood
L-Lactate Dehydrogenase - blood
LDH
Male
Metabolism
Muscle injury
Muscle, Skeletal - enzymology
Muscle, Skeletal - injuries
Muscle, Skeletal - physiology
Physical Exertion - physiology
Procollagen-Proline Dioxygenase - metabolism
Prolyl-4-hydroxylase
Rat
Rats
Rats, Sprague-Dawley
Regeneration - physiology
Space life sciences
Submaximal exercise
β-Glucuronidase
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Summary:To test the effect of low ambient temperature on muscular strain and possible development of muscle injuries, male Sprague-Dawley rats ( n=35) were exercised at a speed of 15 m min −1 on a treadmill at a 6° inclination for 1.5 h in a warm (22°C) or a cold (−10°C) environment. Blood and tissue samples were collected 0 and 48 h postexercise. Blood glucose, lactate, pyruvate, cortisol, epinephrine (E) and norepinephrine (NE) were determined to investigate the effect on energy metabolism. To estimate the degree of physical strain, possible muscle injury and regenerative processes of muscles in response to exercise in the cold, serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle β-glucuronidase and prolyl-4-hydroxylase (PH) activities were measured. In addition, histology of the hindlimb muscles m. soleus and m. tibialis anterior was examined. In general, the circulating level of metabolic substrates during exercise were unaffected by the exercise and independent of ambient temperature. Plasma cortisol increased significantly during exercise ( P
ISSN:1095-6433
1531-4332
DOI:10.1016/S1095-6433(98)10128-9