Antioxidant enzyme and malondialdehyde levels in patients with social phobia

Abstract A growing body of reports have indicated that free radicals are involved in the etiopathogenesis of some neuropsychiatric disorders. In the present study, we aimed to evaluate whether antioxidant enzymes (superoxide dismutase; SOD, glutathione peroxidase; GSH-Px, and catalase; CAT) activity...

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Bibliographic Details
Published in:Psychiatry research 2008-05, Vol.159 (1), p.95-100
Main Authors: Atmaca, Murad, Kuloglu, Murat, Tezcan, Ertan, Ustundag, Bilal
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Antioxidant enzyme
Antioxidants - metabolism
Anxiety disorders. Neuroses
Biological and medical sciences
Catalase - blood
Catalase - metabolism
Control Groups
Diagnostic and Statistical Manual of Mental Disorders
Female
Free Radicals - blood
Free Radicals - metabolism
Glutathione Peroxidase - blood
Glutathione Peroxidase - metabolism
Humans
Lipid Peroxidation
Male
Malondialdehyde - blood
Malondialdehyde - metabolism
MDA
Medical sciences
Middle Aged
Oxidative Stress - physiology
Phobia
Phobic Disorders - blood
Phobic Disorders - diagnosis
Phobic Disorders - enzymology
Psychiatric Status Rating Scales - statistics & numerical data
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Social phobia
Superoxide Dismutase - blood
Superoxide Dismutase - metabolism
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Summary:Abstract A growing body of reports have indicated that free radicals are involved in the etiopathogenesis of some neuropsychiatric disorders. In the present study, we aimed to evaluate whether antioxidant enzymes (superoxide dismutase; SOD, glutathione peroxidase; GSH-Px, and catalase; CAT) activity levels and malondialdehyde (MDA), a product of lipid peroxidation, were associated with social phobia (SP). Eighteen patients diagnosed with SP and 18 healthy controls were enrolled. A clinical evaluation and measurements of MDA, SOD, GSH-Px and CAT were performed. Additionally, all patients were assessed with the Liebowitz Social Anxiety Scale (LSAC). The mean MDA, SOD, GSH-Px and CAT levels in the patient group were significantly higher than those in the control group. There was a positive correlation between LSAC scores and MDA, SOD, GSH-Px and LSAC levels, and between the duration of illness, and MDA, SOD and CAT levels in the patient group. In conclusion, our results suggest that there may be a relationship between increased antioxidant enzyme levels and MDA, and SP.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2002.12.004