Sleep-disordered breathing is related to an increased risk for type 2 diabetes in middle-aged men, but not in women - the FIN-D2D survey

To determine the association between sleep-disordered breathing (SDB) and obesity, diabetes and glucose intolerance among middle-aged men and women in Finland. A multicentre, population-based, cross-sectional survey in Finland. A total of 1396 men and 1500 women aged 45-74 years participated in the...

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Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2008-06, Vol.10 (6), p.468-475
Main Authors: Tuomilehto, H, Peltonen, M, Partinen, M, Seppä, J, Saaristo, T, Korpi-Hyövälti, E, Oksa, H, Saltevo, J, Puolijoki, H, Vanhala, M, Tuomilehto, J
Format: Article
Language:English
Subjects:
Aged
apnoea
Body Mass Index
Cross-Sectional Studies
diabetes
Diabetes Mellitus, Type 2 - epidemiology
Female
Finland - epidemiology
Glucose Intolerance - epidemiology
Humans
Male
Middle Aged
obesity
Obesity - epidemiology
Overweight - epidemiology
Risk Factors
sexes
sleep
Sleep Apnea Syndromes - epidemiology
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Summary:To determine the association between sleep-disordered breathing (SDB) and obesity, diabetes and glucose intolerance among middle-aged men and women in Finland. A multicentre, population-based, cross-sectional survey in Finland. A total of 1396 men and 1500 women aged 45-74 years participated in the survey between 2004 and 2005. The study subjects underwent a health examination including an oral glucose tolerance test and filled a questionnaire describing their sleep habits. Middle-aged men with SDB had an increased prevalence of diabetes and abnormal glucose tolerance. These associations were not found among middle-aged women. After adjustments for age, body mass index, smoking and central nervous system-affecting medication, SDB was independently associated with diabetes and glucose intolerance in men, but not in women. Middle-aged men with SDB have an independent risk of type 2 diabetes. However, both diabetes and SDB exhibit a strong association with obesity and especially with central obesity, reflecting increased visceral fat. In clinical practice especially male patients with diabetes should always be asked about habitual snoring and about possible sleep apnoea.
ISSN:1462-8902
1463-1326
DOI:10.1111/j.1463-1326.2007.00729.x