HIV infection and pathogenesis : What about chemokines?

Several chemotactic cytokines, or chemokines. inhibit HIV replication by blocking or down regulating chemokine receptors that serve as entry cofactors for the virus. Although the role of chemokine receptors in HIV pathogenesis has been the subject of intense interest, chemokines are comparatively le...

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Bibliographic Details
Published in:Journal of clinical immunology 1999-09, Vol.19 (5), p.293-299
Main Authors: GALLO, R. C, GARZINO-DEMO, A, DEVICO, A. L
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Biological and medical sciences
Chemokines - physiology
Chemokines - therapeutic use
HIV - immunology
HIV - pathogenicity
HIV Infections - drug therapy
HIV Infections - etiology
HIV Infections - immunology
HIV Infections - metabolism
Human viral diseases
Humans
Infectious diseases
Medical sciences
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Several chemotactic cytokines, or chemokines. inhibit HIV replication by blocking or down regulating chemokine receptors that serve as entry cofactors for the virus. Although the role of chemokine receptors in HIV pathogenesis has been the subject of intense interest, chemokines are comparatively less seriously considered as potential correlates of protection from HIV infection and disease progression. However, a critical analysis of newly available data reveals substantial evidence to support a beneficial role for chemokines in HIV infection and disease. In this review we summarize the results of such studies and their promising implications for HIV infection.
ISSN:0271-9142
1573-2592
DOI:10.1023/a:1020539524373