Living related liver transplantation in children

Background: Living related liver transplantation (LRLT) has become established for treating children with end‐stage liver disease. The aim of this study was to review a single‐centre experience of left lateral segment liver transplants from living donors in children. Methods: Fifty left lateral segm...

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Bibliographic Details
Published in:British journal of surgery 2008-07, Vol.95 (7), p.919-924
Main Authors: Heaton, N., Faraj, W., Melendez, H. Vilca, Jassem, W., Muiesan, P., Mieli-Vergani, G., Dhawan, A., Rela, M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Child, Preschool
Fathers
Female
General aspects
Graft Rejection
Humans
Immunosuppression - methods
Infant
Liver Diseases - surgery
Liver Neoplasms - surgery
Liver Transplantation - adverse effects
Liver Transplantation - methods
Liver, biliary tract, pancreas, portal circulation, spleen
Living Donors
Male
Medical sciences
Middle Aged
Mothers
Postoperative Care - methods
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
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Summary:Background: Living related liver transplantation (LRLT) has become established for treating children with end‐stage liver disease. The aim of this study was to review a single‐centre experience of left lateral segment liver transplants from living donors in children. Methods: Fifty left lateral segment LRLT procedures have been performed since 1993. There were 17 girls and 33 boys, of median age 1·5 years (range 0·5 to 13 years), with a median weight of 10 (range 0·7–44) kg. Donors included 23 mothers, 26 fathers and one uncle, with a median age of 33 (range 19–46) years. Results: At a median follow‐up of 86 months, there was no donor mortality and low morbidity. Patient and graft survival rates were 98, 96 and 96 per cent, and 98, 96 and 93 per cent at 1, 3 and 5 years respectively. Three children had a second transplant at a median of 9 years after the first. The incidence of hepatic artery thrombosis, portal vein thrombosis and biliary complications was 6, 4 and 14 per cent respectively. Conclusion: Living related liver transplantation has good long‐term results in children. Copyright © 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Good long‐term results
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.6060