Accuracy of ovarian reserve tests

Several tests predict ovarian reserve in women undergoing assisted reproductive technologies. However, the accuracy of these tests in assessing the number of the remaining follicles within the ovary (ovarian reserve) has not been previously validated. The aim of this study was to assess the accuracy...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1999-11, Vol.14 (11), p.2822-2826
Main Authors: Gülekli, Bülent, Bulbul, Yesim, Onvural, Ata, Yorukoglu, Kutsal, Posaci, Cemal, Demir, Namik, Erten, Oktay
Format: Article
Language:English
Subjects:
Adult
ageing
Biological and medical sciences
Buserelin
Clomiphene
Estradiol - blood
Female
Follicle Stimulating Hormone - blood
Follicular Phase
Fundamental and applied biological sciences. Psychology
Humans
Infertility, Female - pathology
Infertility, Female - physiopathology
Mammalian female genital system
Morphology. Physiology
Ovarian Follicle - pathology
ovarian reserve tests
ovary
Ovary - physiopathology
ROC Curve
Sensitivity and Specificity
Vertebrates: reproduction
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Summary:Several tests predict ovarian reserve in women undergoing assisted reproductive technologies. However, the accuracy of these tests in assessing the number of the remaining follicles within the ovary (ovarian reserve) has not been previously validated. The aim of this study was to assess the accuracy of ovarian reserve tests, namely basal and clomiphene-stimulated follicle stimulating hormone (FSH) concentrations and gonadotrophin-releasing hormone (GnRH) agonist stimulation test in predicting the number of the follicles within the ovaries. The ovaries of 22 parous women over 35 years of age who underwent oophorectomy were examined histologically for follicle number. Early follicular phase serum FSH, clomiphene citrate challenge tests (CCCT) and GnRH agonist stimulation test (GAST) were performed in the menstrual cycle prior to the surgery. The predictive value of these tests was then assessed. A positive correlation was detected between basal serum oestradiol concentrations and follicles per unit tissue but no significant correlation was detected between basal and clomiphene-stimulated FSH and follicles per unit tissue. The receiver operator characteristic curves indicated that the clomiphene citrate challenge test was the most accurate of the three tests assessed. In conclusion, none of the tests in this study accurately reflects ovarian reserve.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/14.11.2822