The major histocompatibility complex and the chemosensory signalling of individuality in humans

The chemosensory identity of mice and rats is determined partly by polymorphic genes of the major histocompatibility complex (MHC). In inbred strains of mice, as well as in seminatural populations, MHC-associated mating preferences selectively influence reproductive success, thus serving to promote...

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Bibliographic Details
Published in:Genetica 1998-01, Vol.104 (3), p.265-273
Main Authors: Eggert, F, Luszyk, D, Haberkorn, K, Wobst, B, Vostrowsky, O, Westphal, E, Bestmann, H J, Müller-Ruchholtz, W, Ferstl, R
Format: Article
Language:English
Subjects:
Animals
Breeding success
Chemoreception
Chemoreceptor Cells - physiology
Chromatography, Gas
Discrimination (Psychology) - physiology
Female
Gas chromatography
HLA Antigens - genetics
Humans
Inbreeding
Individuality
Major histocompatibility complex
Major Histocompatibility Complex - physiology
Male
Odorants
Odors
Olfactory discrimination
Olfactory stimuli
Rats
Rats, Inbred Strains
Reference Values
Reproduction
Rodents
Smell - genetics
Smell - immunology
Urine
Urine - chemistry
Urine odors
Volatiles
Volatilization
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Summary:The chemosensory identity of mice and rats is determined partly by polymorphic genes of the major histocompatibility complex (MHC). In inbred strains of mice, as well as in seminatural populations, MHC-associated mating preferences selectively influence reproductive success, thus serving to promote heterozygocity in the MHC. In order to determine whether MHC-associated chemosignals are present in humans, two studies were conducted. In a first study, olfactory identification of MHC-associated chemosignals was conducted on 12 trained rats' responses to the urine odors of humans. In a second study, MHC-associated olfactory cues in humans were analyzed by means of gas chromatography. The results indicate that the urine odors of humans are associated with the MHC and demonstrate that the profile of volatile components in the urine odors shows some association with the MHC. Furthermore, results show that a profile of some specific components, as well as a few ubiquitous volatiles, constitutes MHC-associated odor signals in humans.
ISSN:0016-6707
1573-6857
DOI:10.1023/A:1026431303879