Topical capsaicin application causes cold hypersensitivity in awake monkeys

Recent animal studies have demonstrated that many trigeminal ganglion neurons co-express TRPV1 and TRPA1 receptors following peripheral inflammation. In the present study, we examined whether cold receptors were sensitized by capsaicin in awake monkeys. Two monkeys were trained to detect a change in...

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Bibliographic Details
Published in:Journal of Oral Science 2008, Vol.50(2), pp.175-179
Main Authors: Kamo, Hiroshi, Honda, Kuniya, Kitagawa, Junichi, Tsuboi, Yoshiyuki, Kondo, Masahiro, Taira, Masato, Yamashita, Akiko, Katsuyama, Narumi, Masuda, Yuji, Kato, Takafumi, Iwata, Koichi
Format: Article
Language:English
Subjects:
Administration, Cutaneous
allodynia
Animals
capsaicin
Capsaicin - administration & dosage
Capsaicin - pharmacology
cold hyperalgesia
Cold Temperature
Dentistry
Face - innervation
Macaca
monkey
Reaction Time - drug effects
Sensory System Agents - administration & dosage
Sensory System Agents - pharmacology
Sensory Thresholds - drug effects
Skin - drug effects
Skin - innervation
temperature sense
Thermoreceptors - drug effects
TRPV Cation Channels - drug effects
Wakefulness
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Summary:Recent animal studies have demonstrated that many trigeminal ganglion neurons co-express TRPV1 and TRPA1 receptors following peripheral inflammation. In the present study, we examined whether cold receptors were sensitized by capsaicin in awake monkeys. Two monkeys were trained to detect a change in cold stimulus temperature (30°C to 0.5, 1.0, 1.5 or 2.0°C) applied to the facial skin. A total of 589 trials were studied, and the number of escape and hold-through trials and detection latency were measured. The number of escape trials was increased after capsaicin treatment, whereas that of hold-through trials was decreased. Detection latency was significantly decreased after capsaicin treatment. The present findings suggest that topical application of capsaicin to the facial skin induces reversible hypersensitivity to a facial cold stimulus in behaving monkeys. (J. Oral Sci. 50, 175-179, 2008)
ISSN:1343-4934
1880-4926
DOI:10.2334/josnusd.50.175