The Effect of Movement Amplitude on Activation in Functional Magnetic Resonance Imaging Studies

To evaluate the effect of movement amplitude on the “blood oxygen level-dependent effect,” the authors studied six normal subjects while they extended their index finger with two different amplitudes, Images were analyzed using SPM96, In five subjects, the signal intensity increase in the primary se...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1999-11, Vol.19 (11), p.1209-1212
Main Authors: Waldvogel, Daniel, van Gelderen, Peter, Ishii, Kenji, Hallett, Mark
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Fingers - physiology
Humans
Image Processing, Computer-Assisted
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Medical sciences
Middle Aged
Motor Activity - physiology
Motor Cortex - diagnostic imaging
Motor Cortex - physiology
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiography
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Summary:To evaluate the effect of movement amplitude on the “blood oxygen level-dependent effect,” the authors studied six normal subjects while they extended their index finger with two different amplitudes, Images were analyzed using SPM96, In five subjects, the signal intensity increase in the primary sensorimotor area was significantly greater with the larger amplitude movement. In other areas of interest (supplementary motor area, premotor cortex, insula, postcentral area, cerebellum), the large-amplitude movement often showed significant activation when the small-amplitude movement did not. The authors conclude that, in studies of the motor system, movement amplitude needs to be controlled.
ISSN:0271-678X
1559-7016
DOI:10.1097/00004647-199911000-00004