Immunohistochemical study of fatty acid synthase, Ki67, proliferating cell nuclear antigen, and p53 expression in hyperplastic parathyroids

Patients with secondary hyperparathyroidism following chronic renal disease frequently develop hyperplastic parathyroids. Hyperplastic parathyroids have an increased number of chief cells, a decreased amount of stromal fat, and a nodular or diffuse histologic pattern. Hyperplastic parathyroids may a...

Full description

Saved in:
Bibliographic Details
Published in:Annals of diagnostic pathology 1999-10, Vol.3 (5), p.287-293
Main Authors: Aló, Piero L., Visca, Paolo, Mazzaferro, Sandro, Serpieri, Daniele Eleuteri, Mangoni, Antonella, Botti, Claudio, Monaco, Simona, Carboni, Manlio, Zaraca, Francesco, Trombetta, Giorgio, Di Tondo, Ugo
Format: Article
Language:English
Subjects:
Adult
Aged
Fatty Acid Synthases - metabolism
Female
Humans
Hyperparathyroidism, Secondary - etiology
Hyperparathyroidism, Secondary - metabolism
Hyperparathyroidism, Secondary - surgery
Hyperplasia
Immunoenzyme Techniques
Ki-67 Antigen - metabolism
Kidney Failure, Chronic - complications
Male
Middle Aged
Parathyroid Glands - metabolism
Parathyroid Glands - pathology
Parathyroidectomy
Proliferating Cell Nuclear Antigen - metabolism
Tumor Suppressor Protein p53 - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Patients with secondary hyperparathyroidism following chronic renal disease frequently develop hyperplastic parathyroids. Hyperplastic parathyroids have an increased number of chief cells, a decreased amount of stromal fat, and a nodular or diffuse histologic pattern. Hyperplastic parathyroids may also express higher proliferative activity compared with controls. We evaluated the morphologic features and immunohistochemical expression of fatty acid synthase (FAS), Ki67, proliferating cell nuclear antigen, and p53 protein in 78 hyperplastic parathyroids from 20 patients with secondary hyperparathyroidism. Twenty normal parathyroids incidentally removed during nonneoplastic thyroid surgery were used as controls. Our results showed that hyperplastic glands overexpress FAS ( P = .06). Statistical analysis also revealed a significant association between FAS and p53 protein ( P = .006) and between FAS and hyperplastic glands with a predominant nodular pattern ( P = .02). Hyperplastic parathyroids from patients with chronic renal failure strongly express FAS. Fatty acid synthase may therefore be a potential biological indicator of highly proliferating parathyroid cells.
ISSN:1092-9134
1532-8198
DOI:10.1016/S1092-9134(99)80024-0