Simple sequence repeats: genetic modulators of brain function and behavior

• Published in: Trends in neurosciences (Regular ed.) 2008-07, Vol.31 (7), p.328-334
• Main Authors: Fondon, John W, Hammock, Elizabeth A.D, Hannan, Anthony J, King, David G
• Format: Article
• Language: English
• Subjects: Animals; Behavior; Behavior - physiology; Biological and medical sciences; Brain; Brain - physiology; Chronobiology; Deoxyribonucleic acid; DNA; Fundamental and applied biological sciences. Psychology; General aspects. Models. Methods; Genetics; Humans; Minisatellite Repeats - physiology; Mutation; Neurological disorders; Neurology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: nervous system and sense organs
• ISSN: 0166-2236; 1878-108X
• DOI: 10.1016/j.tins.2008.03.006

Simple sequence repeats (SSRs), sometimes described as genetic ‘stutters,’ are DNA tracts in which a short base-pair motif is repeated several to many times in tandem (e.g. CAGCAGCAG). These sequences experience frequent mutations that alter the number of repeats. Because SSRs are commonly located in promoters, untranslated regions and even coding sequences, such mutations can directly influence almost any aspect of gene function. Mutational expansion of certain triplet repeats is responsible for several hereditary neurodegenerative disorders, but SSR alleles can also contribute to normal variation in brain and behavioral traits. Here we review studies implicating SSRs not just in disease but also in circadian rhythmicity, sociosexual interaction, aggression, cognition and personality. SSRs can affect neuronal differentiation, brain development and even behavioral evolution.