Effect of Duodenal Glucose and Acute Hyperglycemia on Rectal Perception and Compliance in Response to Tension-controlled Rectal Distension in Healthy Humans

Background Acute changes in blood glucose concentration affect gastrointestinal motor and sensory function. Tone and distensibility contribute to intact rectal function. Aims To test the effects of duodenal glucose (euglycemic hyperinsulinemia), intravenous glucose (hyperglycemic hyperinsulinemia),...

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Bibliographic Details
Published in:Digestive diseases and sciences 2008-06, Vol.53 (6), p.1624-1631
Main Authors: Hernando-Harder, Ana Cristina, Singer, Manfred Vincenz, Harder, Hermann
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Analysis of Variance
Biochemistry
Biological and medical sciences
Duodenum - metabolism
Duodenum - physiopathology
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology
Glucose - metabolism
Glucose Clamp Technique
Glucose Tolerance Test
Hepatology
Humans
Hyperglycemia - metabolism
Hyperglycemia - physiopathology
Male
Medicine
Medicine & Public Health
Oncology
Original Paper
Rectum - physiopathology
Sensation
Statistics, Nonparametric
Transplant Surgery
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Background Acute changes in blood glucose concentration affect gastrointestinal motor and sensory function. Tone and distensibility contribute to intact rectal function. Aims To test the effects of duodenal glucose (euglycemic hyperinsulinemia), intravenous glucose (hyperglycemic hyperinsulinemia), and saline (euglycemic normoinsulinemia as control) on rectal perception and compliance in response to tension-controlled rectal distension. Methods During duodenal glucose at 2 kcal min −1 , marked hyperglycemic clamp (∼13 mmol L −1 ), or saline as control, responses to fixed-tension rectal distension, applied by means of a computerized tensostat, were compared randomized on three separate days in eight healthy subjects. Results At discomfort level (score 3 on the 0–4 rectal score scale), perception of rectal distension was significantly higher during euglycemic hyperinsulinemia (45 ± 3 g cm −2 tolerance) and significantly lower during hyperglycemia (83 ± 4 g cm −2 tolerance), both reaching significance versus control (64 ± 6 g cm −2 tolerance; P  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-007-0032-x