Perioperative functional activity of the alternative pathway of complement in patients with colonic cancer

Objective: To investigate the functional capacity of the alternative pathway of complement in patients with cancer of the colon before, during, and after operation. Design: Prospective study. Setting: One university and two district hospitals, Denmark. Subjects: 28 patients having elective or emerge...

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Bibliographic Details
Published in:The European journal of surgery 1999-10, Vol.165 (10), p.962-965
Main Authors: Baatrup, Gunnar, Zimmermann-Nielsen, Erik, Qvist, Niels
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Colonic Neoplasms - immunology
Colonic Neoplasms - surgery
Complement C3b - metabolism
Complement Fixation Tests
Complement Pathway, Alternative - immunology
Enzyme-Linked Immunosorbent Assay
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Middle Aged
Monitoring, Intraoperative
Postoperative Complications - immunology
Prospective Studies
Reference Values
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Objective: To investigate the functional capacity of the alternative pathway of complement in patients with cancer of the colon before, during, and after operation. Design: Prospective study. Setting: One university and two district hospitals, Denmark. Subjects: 28 patients having elective or emergency operations for colonic cancer. Interventions: Measurements of C3b fixing capacity of the alternative complement pathway in serum before, during, and after operation. Main outcome measurements: The functional capacity of the alternative pathway of complement, and changes during operation. Results: The functional capacity of the alternative pathway in patients with cancer of the colon was above normal (p < 0.0001 for both men and women), and the capacity remained unchanged during operation despite dilution of serum peroperatively. Conclusion: The alternative pathway seems to be the only immunological variable that has so far been shown to have increased functional capacity in patients with cancer, and that remains unaltered (mean value) during operation. The importance of retaining normal function of the alternative complement pathway in the prevention of postoperative infective complications and recurrence of cancer has not yet been elucidated. Copyright © 1999 Taylor and Francis Ltd.
ISSN:1102-4151
1741-9271
DOI:10.1080/110241599750008080