Clinical Significance of Selected Endothelial Activation Markers in Patients with Systemic Lupus Erythematosus

• Published in: Journal of rheumatology 2008-07, Vol.35 (7), p.1307-1313
• Main Authors: KURYLISZYN-MOSKAL, Anna, KLIMIUK, Piotr Adrian, CIOLKIEWICZ, Mariusz, SIERAKOWSKI, Stanislaw
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological and medical sciences; Biomarkers - blood; Case-Control Studies; Diseases of the osteoarticular system; E-Selectin - blood; Endothelial Cells - immunology; Endothelin-1 - blood; Endothelium, Vascular - immunology; Female; Humans; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - physiopathology; Male; Medical sciences; Middle Aged; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Thrombomodulin - blood
• ISSN: 0315-162X; 1499-2752

Objective Systemic lupus erythematosus (SLE) is an autoimmune disease in which immunologically mediated vascular endothelial cell activation is regarded as a potential pathophysiological mechanism of systemic organ damage. We investigated selected endothelial cell activation markers in serum of patients with SLE and their relationships with systemic organ manifestations and disease activity. Methods Serum levels of endothelin-1 (ET-1), soluble E-selectin, and thrombomodulin (sTM) were determined by ELISA in 76 SLE patients and in 34 healthy controls. Results Higher serum concentrations of ET-1, sE-selectin (p < 0.05), and sTM (p < 0.001) were observed in SLE patients in comparison with controls. Significant differences of ET-1, (p < 0.01), sTM (p < 0.001), and sE-selectin serum concentrations (p < 0.01) were found between SLE patients with systemic involvement and controls. Patients with organ manifestations (n = 34) showed significantly higher serum levels of ET-1 than patients without systemic involvement (n = 42) (p < 0.05). Comparison between patients with active and inactive SLE according to SLE Disease Activity Index (SLEDAI) score showed significantly higher concentration of ET-1 in the sera of patients with active SLE compared with inactive patients and the controls (p < 0.001). Conclusion Our findings suggest that the elevated serum concentrations of ET-1, sTM, and sE-selectin reflect persisting endothelial cell activation in SLE, and point to an important role of ET-1 in the pathogenesis of internal organ involvement. Moreover, elevated ET-1 concentrations are related to disease activity, suggesting a key role of endothelial cell activation in systemic manifestations in SLE patients. Key Indexing Terms: ENDOTHELIAL ACTIVATION MARKERS SYSTEMIC LUPUS ERYTHEMATOSUS ENDOTHELIN-1 E-SELECTIN THROMBOMODULIN