Low Levels of Hepatitis C Virus (HCV) Neutralizing Antibodies in Patients Coinfected with HCV and Human Immunodeficiency Virus

The hepatitis C virus (HCV) neutralizing antibody (nAb) response in 37 subjects with HCV monoinfection and 37 HCV-infected subjects with well-controlled human immunodeficiency virus (HIV) infection was evaluated using a focus reduction neutralization assay. HCV nAb levels were retrospectively studie...

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Bibliographic Details
Published in:The Journal of infectious diseases 2008-08, Vol.198 (3), p.332-335
Main Authors: Castelain, Sandrine, Schnuriger, Aurélie, François, Catherine, Nguyen-Khac, Eric, Fournier, Carole, Schmit, Jean-Luc, Capron, Dominique, Dubuisson, Jean, Wychowski, Czeslaw, Thibault, Vincent, Duverlie, Gilles
Format: Article
Language:English
Subjects:
Adult
Antibodies
Biological and medical sciences
Case-Control Studies
Female
Fundamental and applied biological sciences. Psychology
Genotypes
Hepacivirus
Hepacivirus - immunology
Hepatitis C
Hepatitis C - complications
Hepatitis C - immunology
Hepatitis C Antibodies - blood
Hepatitis C virus
HIV
HIV - isolation & purification
HIV infections
HIV Infections - complications
HIV Infections - immunology
HIV/AIDS
Human immunodeficiency virus
Humans
Infections
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Neutralization Tests
Neutralizing antibodies
Retrospective Studies
T lymphocytes
Viral Load
Virology
Viruses
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Description
Summary:The hepatitis C virus (HCV) neutralizing antibody (nAb) response in 37 subjects with HCV monoinfection and 37 HCV-infected subjects with well-controlled human immunodeficiency virus (HIV) infection was evaluated using a focus reduction neutralization assay. HCV nAb levels were retrospectively studied in both groups of patients, who were matched on the basis of sex, age, and HCV genotype. The mean HCV nAb level (± standard deviation) among coinfected patients (1.613±0.416) was significantly less than that among monoinfected patients (1.912±0.578) (P=.013). Lower HCV nAb titers in coinfected patients could help worsen the outcome of HCV infection. These results favor starting HCV therapy as soon as possible in coinfected patients.
ISSN:0022-1899
1537-6613
DOI:10.1086/589777