Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity

Compounds known to disrupt exocytosis or endocytosis were introduced into CA1 pyramidal cells while monitoring excitatory postsynaptic currents (EPSCs). Disrupting exocytosis or the interaction of GluR2 with NSF caused a gradual reduction in the AMPAR EPSC, while inhibition of endocytosis caused a g...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 1999-11, Vol.24 (3), p.649-658
Main Authors: Lüscher, Christian, Xia, Houhui, Beattie, Eric C, Carroll, Reed C, von Zastrow, Mark, Malenka, Robert C, Nicoll, Roger A
Format: Article
Language:English
Subjects:
Animals
Carrier Proteins - physiology
Endocytosis - physiology
Exocytosis - physiology
In Vitro Techniques
Long-Term Potentiation - physiology
N-Ethylmaleimide-Sensitive Proteins
Neuronal Plasticity - physiology
Rats
Rats, Sprague-Dawley
Receptors, AMPA - physiology
Synapses - physiology
Synaptic Transmission - physiology
Vesicular Transport Proteins
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Summary:Compounds known to disrupt exocytosis or endocytosis were introduced into CA1 pyramidal cells while monitoring excitatory postsynaptic currents (EPSCs). Disrupting exocytosis or the interaction of GluR2 with NSF caused a gradual reduction in the AMPAR EPSC, while inhibition of endocytosis caused a gradual increase in the AMPAR EPSC. These manipulations had no effect on the NMDAR EPSC but prevented the subsequent induction of LTD. These results suggest that AMPARs, but not NMDARs, cycle into and out of the synaptic membrane at a rapid rate and that certain forms of synaptic plasticity may utilize this dynamic process.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(00)81119-8